Clement Chapat
Overview
Explore the profile of Clement Chapat including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
431
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Recent Articles
1.
Oudart M, Avila-Gutierrez K, Moch C, Dossi E, Milior G, Boulay A, et al.
Cell Rep
. 2023 May;
42(5):112456.
PMID: 37126448
The regulation of translation in astrocytes, the main glial cells in the brain, remains poorly characterized. We developed a high-throughput proteomics screen for polysome-associated proteins in astrocytes and focused on...
2.
Zou L, Moch C, Graille M, Chapat C
iScience
. 2022 Jun;
25(7):104646.
PMID: 35756894
There is an urgent need for a molecular understanding of how SARS-CoV-2 influences the machineries of the host cell. Herein, we focused our attention on the capacity of the SARS-CoV-2...
3.
Zhang X, Chapat C, Wang P, Choi J, Li Q, Luo J, et al.
Mol Cell
. 2021 Feb;
81(6):1187-1199.e5.
PMID: 33581076
Type I interferons (IFNs) are critical cytokines in the host defense against invading pathogens. Sustained production of IFNs, however, is detrimental to the host, as it provokes autoimmune diseases. Thus,...
4.
Hazra D, Chapat C, Graille M
Genes (Basel)
. 2019 Jan;
10(1).
PMID: 30650668
The control of gene expression is a multi-layered process occurring at the level of DNA, RNA, and proteins. With the emergence of highly sensitive techniques, new aspects of RNA regulation...
5.
Jafarnejad S, Chapat C, Matta-Camacho E, Gelbart I, Hesketh G, Arguello M, et al.
Elife
. 2018 Feb;
7.
PMID: 29412140
MicroRNAs (miRNAs) exert a broad influence over gene expression by directing effector activities that impinge on translation and stability of mRNAs. We recently discovered that the cap-binding protein 4EHP is...
6.
Garzia A, Jafarnejad S, Meyer C, Chapat C, Gogakos T, Morozov P, et al.
Nat Commun
. 2017 Jul;
8:16056.
PMID: 28685749
Cryptic polyadenylation within coding sequences (CDS) triggers ribosome-associated quality control (RQC), followed by degradation of the aberrant mRNA and polypeptide, ribosome disassembly and recycling. Although ribosomal subunit dissociation and nascent...
7.
Chapat C, Chettab K, Simonet P, Wang P, De La Grange P, Le Romancer M, et al.
Nucleic Acids Res
. 2017 Jun;
45(14):8508-8523.
PMID: 28591869
The CCR4-associated factor CAF1, also called CNOT7, is a catalytic subunit of the CCR4-NOT complex, which has been implicated in all aspects of the mRNA life cycle, from mRNA synthesis...
8.
Gantois I, Khoutorsky A, Popic J, Aguilar-Valles A, Freemantle E, Cao R, et al.
Nat Med
. 2017 May;
23(6):674-677.
PMID: 28504725
Fragile X syndrome (FXS) is the leading monogenic cause of autism spectrum disorders (ASD). Trinucleotide repeat expansions in FMR1 abolish FMRP expression, leading to hyperactivation of ERK and mTOR signaling...
9.
Chapat C, Jafarnejad S, Matta-Camacho E, Hesketh G, Gelbart I, Attig J, et al.
Proc Natl Acad Sci U S A
. 2017 May;
114(21):5425-5430.
PMID: 28487484
MicroRNAs (miRNAs) play critical roles in a broad variety of biological processes by inhibiting translation initiation and by destabilizing target mRNAs. The CCR4-NOT complex effects miRNA-mediated silencing, at least in...
10.
Wu E, Vashisht A, Chapat C, Flamand M, Cohen E, Sarov M, et al.
Nucleic Acids Res
. 2017 Feb;
45(4):2081-2098.
PMID: 28204614
MicroRNAs (miRNAs) impinge on the translation and stability of their target mRNAs, and play key roles in development, homeostasis and disease. The gene regulation mechanisms they instigate are largely mediated...