Cleiton F Machado
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Explore the profile of Cleiton F Machado including associated specialties, affiliations and a list of published articles.
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7
Citations
174
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Recent Articles
1.
Machado C, Reis-Silva T, Lyra C, Felicio L, Malnic B
Bio Protoc
. 2021 Jul;
8(12):e2897.
PMID: 34286006
The sense of smell allows animals to discriminate a large number of volatile environmental chemicals. Such chemical signaling modulates the behavior of several species that depend on odorant compounds to...
2.
Nagai M, Xavier V, Gutiyama L, Machado C, Reis A, Donnard E, et al.
PLoS Genet
. 2020 May;
16(5):e1008255.
PMID: 32392211
mTOR, a serine/threonine protein kinase that is involved in a series of critical cellular processes, can be found in two functionally distinct complexes, mTORC1 and mTORC2. In contrast to mTORC1,...
3.
Machado C, Nagai M, Lyra C, Reis-Silva T, Xavier A, Glezer I, et al.
J Neurosci
. 2017 Nov;
37(50):12202-12213.
PMID: 29118104
The olfactory system can discriminate a vast number of odorants. This ability derives from the existence of a large family of odorant receptors expressed in the cilia of the olfactory...
4.
Machado C, Beraldo F, Santos T, Bourgeon D, Landemberger M, Roffe M, et al.
J Biol Chem
. 2012 Nov;
287(52):43777-88.
PMID: 23132868
Prions, the agents of transmissible spongiform encephalopathies, require the expression of prion protein (PrP(C)) to propagate disease. PrP(C) is converted into an abnormal insoluble form, PrP(Sc), that gains neurotoxic activity....
5.
Caetano F, Beraldo F, Hajj G, Guimaraes A, Jurgensen S, Wasilewska-Sampaio A, et al.
J Neurochem
. 2011 Mar;
117(3):538-53.
PMID: 21352228
In Alzheimer's disease, the amyloid-β peptide (Aβ) interacts with distinct proteins at the cell surface to interfere with synaptic communication. Recent data have implicated the prion protein (PrP(C)) as a...
6.
Beraldo F, Arantes C, Santos T, Machado C, Roffe M, Hajj G, et al.
FASEB J
. 2010 Sep;
25(1):265-79.
PMID: 20876210
The prion protein (PrP(C)) is highly expressed in the nervous system, and its abnormal conformer is associated with prion diseases. PrP(C) is anchored to cell membranes by glycosylphosphatidylinositol, and transmembrane...
7.
Caetano F, Lopes M, Hajj G, Machado C, Pinto Arantes C, Magalhaes A, et al.
J Neurosci
. 2008 Jun;
28(26):6691-702.
PMID: 18579743
The secreted cochaperone STI1 triggers activation of protein kinase A (PKA) and ERK1/2 signaling by interacting with the cellular prion (PrP(C)) at the cell surface, resulting in neuroprotection and increased...