Marilene H Lopes
Overview
Explore the profile of Marilene H Lopes including associated specialties, affiliations and a list of published articles.
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25
Citations
789
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0
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Recent Articles
1.
Prado M, Coelho B, Iglesia R, Alves R, Boccacino J, Fernandes C, et al.
BMC Cancer
. 2024 Dec;
24(1):1539.
PMID: 39695426
Background: Glioblastoma (GBM) is an aggressive brain tumor driven by glioblastoma stem cells (GSCs), which represent an appealing target for therapeutic interventions. The cellular prion protein (PrP), a scaffold protein...
2.
Lin L, Razzaq A, Di Gregorio S, Hong S, Charles B, Lopes M, et al.
FASEB J
. 2021 Apr;
35(5):e21594.
PMID: 33908654
Protein misfolding is a central feature of most neurodegenerative diseases. Molecular chaperones can modulate the toxicity associated with protein misfolding, but it remains elusive which molecular chaperones and co-chaperones interact...
3.
Lackie R, Razzaq A, Farhan S, Qiu L, Moshitzky G, Beraldo F, et al.
J Neurochem
. 2019 Sep;
153(6):727-758.
PMID: 31562773
Chaperone networks are dysregulated with aging, but whether compromised Hsp70/Hsp90 chaperone function disturbs neuronal resilience is unknown. Stress-inducible phosphoprotein 1 (STI1; STIP1; HOP) is a co-chaperone that simultaneously interacts with...
4.
Cruz L, Romero J, Iglesia R, Lopes M
Front Cell Dev Biol
. 2018 Sep;
6:94.
PMID: 30211159
The blastocyst inner cell mass (ICM) that gives rise to a whole embryo can be derived and cultured as embryonic stem cells (ESCs), which retain full developmental potential. ICM cells...
5.
de Brito G, Lupinacci F, Beraldo F, Santos T, Roffe M, Lopes M, et al.
Biochem J
. 2017 Jul;
474(17):2981-2991.
PMID: 28739602
Prion protein (PrP) was initially described due to its involvement in transmissible spongiform encephalopathies. It was subsequently demonstrated to be a cell surface molecule involved in many physiological processes, such...
6.
Rodrigues B, Queiroz-Hazarbassanov N, Lopes M, Bleggi-Torres L, Suzuki S, Cunha I, et al.
Pathol Res Pract
. 2016 Mar;
212(6):517-23.
PMID: 27013058
Glioblastoma (GBM) is currently the most aggressive form of brain tumor identified, and STAT3 is known to play an important role in gliomagenesis. Moreover, while several studies have used pharmacological...
7.
Santos T, Lopes M, Martins V
Prion
. 2015 Jun;
9(3):165-73.
PMID: 26110608
In recent years, prion protein (PrP(C)) has been considered as a promising target molecule for cancer therapies, due its direct or indirect participation in tumor growth, metastasis, and resistance to...
8.
Soares I, Caetano F, Pinder J, Rodrigues B, Beraldo F, Ostapchenko V, et al.
Mol Cell Proteomics
. 2013 Aug;
12(11):3253-70.
PMID: 23938469
Stress-inducible phosphoprotein 1 (STI1), a cochaperone for Hsp90, has been shown to regulate multiple pathways in astrocytes, but its contributions to cellular stress responses are not fully understood. We show...
9.
Hajj G, Arantes C, Dias M, Roffe M, Costa-Silva B, Lopes M, et al.
Cell Mol Life Sci
. 2013 Apr;
70(17):3211-27.
PMID: 23543276
The co-chaperone stress-inducible protein 1 (STI1) is released by astrocytes, and has important neurotrophic properties upon binding to prion protein (PrP(C)). However, STI1 lacks a signal peptide and pharmacological approaches...
10.
Santos T, Beraldo F, Hajj G, Lopes M, Roffe M, Lupinacci F, et al.
J Neurochem
. 2012 Nov;
124(2):210-23.
PMID: 23145988
Prion protein (PrP(C)) is a cell surface glycoprotein that is abundantly expressed in nervous system. The elucidation of the PrP(C) interactome network and its significance on neural physiology is crucial...