Clayton Mathews
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Explore the profile of Clayton Mathews including associated specialties, affiliations and a list of published articles.
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12
Citations
339
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Recent Articles
1.
Yadav G, Annamalai M, Hagan D, Cui L, Mathews C, Jiang Q
bioRxiv
. 2025 Jan;
PMID: 39763853
Highlights: Loss of CHGB channel functions impairs secretory granule acidification in neuroendocrine cells, which necessitates anion shunt conduction. CHGBΔMIF, a mutant unable to form a functional Cl channel, exerts negative...
2.
De Jesus D, Zhang Z, Brown N, Li X, Xiao L, Hu J, et al.
Nat Cell Biol
. 2024 Feb;
26(3):421-437.
PMID: 38409327
Type 1 diabetes (T1D) is characterized by the destruction of pancreatic β-cells. Several observations have renewed the interest in β-cell RNA sensors and editors. Here, we report that -methyladenosine (mA)...
3.
Leung S, Lenchik N, Mathews C, Pugliese A, McCarthy D, Le Bagge S, et al.
Sci Rep
. 2023 Aug;
13(1):12948.
PMID: 37558746
Hypoglycemia in type 1 diabetes associates with changes in the pancreatic islet α cells, where the receptor for advanced glycation end products (RAGE) is highly expressed. This study compared islet...
4.
De Jesus D, Zhang Z, Brown N, Li X, Gaffrey M, Kahraman S, et al.
bioRxiv
. 2023 Feb;
PMID: 36824909
Type 1 Diabetes (T1D) is characterized by autoimmune-mediated destruction of insulin-producing β-cells. Several observations have renewed interest in the innate immune system as an initiator of the disease process against...
5.
Krogvold L, Leete P, Mynarek I, Russell M, Gerling I, Lenchik N, et al.
Front Endocrinol (Lausanne)
. 2022 Aug;
13:881997.
PMID: 35957810
Aims/hypothesis: The Diabetes Virus Detection (DiViD) study has suggested the presence of low-grade enteroviral infection in pancreatic tissue collected from six of six live adult patients newly diagnosed with type...
6.
Valikangas T, Lietzen N, Jaakkola M, Krogvold L, Eike M, Kallionpaa H, et al.
Front Endocrinol (Lausanne)
. 2022 May;
13:861985.
PMID: 35498413
Although type 1 diabetes (T1D) is primarily a disease of the pancreatic beta-cells, understanding of the disease-associated alterations in the whole pancreas could be important for the improved treatment or...
7.
Gioia L, Holt M, Costanzo A, Sharma S, Abe B, Kain L, et al.
Sci Immunol
. 2019 Sep;
4(38).
PMID: 31471352
The class II region of the major histocompatibility complex (MHC) locus is the main contributor to the genetic susceptibility to type 1 diabetes (T1D). The loss of an aspartic acid...
8.
Babon J, DeNicola M, Blodgett D, Crevecoeur I, Buttrick T, Maehr R, et al.
Nat Med
. 2017 Aug;
23(8):1004.
PMID: 28777787
No abstract available.
9.
Babon J, DeNicola M, Blodgett D, Crevecoeur I, Buttrick T, Maehr R, et al.
Nat Med
. 2017 Feb;
23(2):264.
PMID: 28170374
No abstract available.
10.
Babon J, DeNicola M, Blodgett D, Crevecoeur I, Buttrick T, Maehr R, et al.
Nat Med
. 2016 Nov;
22(12):1482-1487.
PMID: 27798614
A major therapeutic goal for type 1 diabetes (T1D) is to induce autoantigen-specific tolerance of T cells. This could suppress autoimmunity in those at risk for the development of T1D,...