Claudia N Tomes
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Explore the profile of Claudia N Tomes including associated specialties, affiliations and a list of published articles.
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23
Citations
437
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Recent Articles
1.
Di Bartolo A, Tomes C, Mayorga L, Masone D
J Chem Theory Comput
. 2022 Jun;
18(7):4544-4554.
PMID: 35759758
The fusion pore controls the release of exocytotic vesicle contents through a precise orchestration of lipids from the fusing membranes and proteins. There is a major lipid reorganization during the...
2.
Caparotta M, Tomes C, Mayorga L, Masone D
J Chem Theory Comput
. 2020 Nov;
16(12):7840-7851.
PMID: 33166466
Fusion pores serve as an effective mechanism to connect intracellular organelles and release vesicle contents during exocytosis. A complex lipid rearrangement takes place as membranes approximate, bend, fuse, and establish...
3.
Moreno-Irusta A, Dominguez E, Marin-Briggiler C, Matamoros-Volante A, Lucchesi O, Tomes C, et al.
Reproduction
. 2020 Jan;
159(4):423-436.
PMID: 31967971
Sperm chemotaxis may facilitate the finding of the oocyte. Only capacitated spermatozoa can orient their movement by chemotaxis, which as well as capacitation, is regulated in part by the cAMP-PKA...
4.
Bustos M, Lucchesi O, Ruete M, Tomes C
Cell Signal
. 2018 Jan;
44:72-81.
PMID: 29337043
The acrosome reaction is the regulated exocytosis of mammalian sperm's single secretory granule, essential for fertilization. It relies on small GTPases, the cAMP binding protein Epac, and the SNARE complex,...
5.
Quevedo M, Lucchesi O, Bustos M, Pocognoni C, de la Iglesia P, Tomes C
J Biol Chem
. 2016 Sep;
291(44):23101-23111.
PMID: 27613869
At the final stage of exocytotis, a fusion pore opens between the plasma and a secretory vesicle membranes; typically, when the pore dilates the vesicle releases its cargo. Sperm contain...
6.
Belmonte S, Mayorga L, Tomes C
Adv Anat Embryol Cell Biol
. 2016 May;
220:71-92.
PMID: 27194350
Exocytosis is a fundamental process used by eukaryotic cells to release biological compounds and to insert lipids and proteins in the plasma membrane. Specialized secretory cells undergo regulated exocytosis in...
7.
Lucchesi O, Ruete M, Bustos M, Quevedo M, Tomes C
Biochim Biophys Acta
. 2015 Dec;
1863(4):544-61.
PMID: 26704387
Exocytosis of the sperm's single secretory granule, or acrosome, is a regulated exocytosis triggered by components of the egg's investments. In addition to external calcium, sperm exocytosis (termed the acrosome...
8.
Bustos M, Lucchesi O, Ruete M, Mayorga L, Tomes C
Methods Mol Biol
. 2015 Mar;
1298:141-60.
PMID: 25800839
Regulated exocytosis employs a conserved molecular machinery in all secretory cells. Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) and Rab superfamilies are members of this machinery. Rab proteins are small...
9.
Ruete M, Lucchesi O, Bustos M, Tomes C
Cell Commun Signal
. 2014 Aug;
12:43.
PMID: 25159528
Background: Exocytosis of sperm's single secretory granule or acrosome (acrosome reaction, AR) is a highly regulated event essential for fertilization. The AR begins with an influx of calcium from the...
10.
Bustos M, Roggero C, de la Iglesia P, Mayorga L, Tomes C
J Mol Cell Biol
. 2014 Jul;
6(4):286-98.
PMID: 25053757
Exocytosis of mammalian sperm dense-core secretory granule relies on the same fusion molecules as all other secretory cells; one such molecule is the small GTPase Rab3A. Here, we report an...