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Claudia L da Silva

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Articles 59
Citations 825
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Recent Articles
1.
Madan E, Palma A, Vudatha V, Kumar A, Bhoopathi P, Wilhelm J, et al.
Nat Biotechnol . 2024 Dec; PMID: 39653752
Cell competition and fitness comparison between cancer and tumor microenvironment (TME) cells determine oncogenic fate. Our previous study established a role for human Flower isoforms as fitness fingerprints, where the...
2.
Goncalves P, da Silva C, Bernardes N
Adv Cancer Res . 2024 Sep; 163:137-185. PMID: 39271262
Cancer remains as one of the highest challenges to human health. However, anticancer drugs exhibit one of the highest attrition rates compared to other therapeutic interventions. In part, this can...
3.
Branco A, Rayabaram J, Miranda C, Fernandes-Platzgummer A, Fernandes T, Sajja S, et al.
Front Bioeng Biotechnol . 2024 Jun; 12:1380950. PMID: 38846805
As caretakers of the hematopoietic system, hematopoietic stem cells assure a lifelong supply of differentiated populations that are responsible for critical bodily functions, including oxygen transport, immunological protection and coagulation....
4.
Bandarra-Tavares H, Franchi-Mendes T, Ulpiano C, Morini S, Kaur N, Harris-Becker A, et al.
Cytotherapy . 2024 Mar; 26(7):749-756. PMID: 38506771
Background & Aims: Cell therapies based on mesenchymal stromal cells (MSCs) have gained an increasing therapeutic interest in the context of multiple disorders. Nonetheless, this field still faces important challenges,...
5.
Marques C, Campos J, Sampaio-Marques B, Antunes F, Dos Santos Cunha R, Silva D, et al.
Cytotherapy . 2024 Mar; 26(7):700-713. PMID: 38483360
Background Aims: Parkinson's disease (PD) is the second most common neurodegenerative disorder. The etiology of the disease remains largely unknown, but evidence have suggested that the overexpression and aggregation of...
6.
Pinto C, Branco A, Bucar S, Fonseca A, Abrunhosa A, da Silva C, et al.
EJNMMI Res . 2024 Mar; 14(1):26. PMID: 38453813
Background: Glioblastoma is an extremely aggressive malignant tumor with a very poor prognosis. Due to the increased proliferation rate of glioblastoma, there is the development of hypoxic regions, characterized by...
7.
Cartaxo A, Fernandes-Platzgummer A, Rodrigues C, Melo A, Tecklenburg K, Margreiter E, et al.
Tissue Eng Part C Methods . 2023 Oct; 29(12):583-595. PMID: 37842845
Fecal incontinence, although not life-threatening, has a high impact on the economy and patient quality of life. So far, available treatments are based on both surgical and nonsurgical approaches. These...
8.
Franchi-Mendes T, Silva M, Cartaxo A, Fernandes-Platzgummer A, Cabral J, da Silva C
Bioengineering (Basel) . 2023 Sep; 10(9). PMID: 37760170
Tissue engineering approaches within the muscle context represent a promising emerging field to address the current therapeutic challenges related with multiple pathological conditions affecting the muscle compartments, either skeletal muscle...
9.
Fernandes-Platzgummer A, Cunha R, Morini S, Carvalho M, Moreno-Cid J, Garcia C, et al.
Biotechnol Bioeng . 2023 Jun; 120(9):2742-2755. PMID: 37318000
The therapeutic effects of human mesenchymal stromal cells (MSC) have been attributed mostly to their paracrine activity, exerted through small-secreted extracellular vesicles (EVs) rather than their engraftment into injured tissues....
10.
Alves L, Machado V, Botelho J, Mendes J, Cabral J, da Silva C, et al.
Biomedicines . 2023 May; 11(5). PMID: 37239023
Cell-based therapies using periodontal ligament stromal cells (PDLSC) for periodontal regeneration may represent an alternative source for mesenchymal stromal cells (MSC) to MSC derived from bone marrow (MSC(M)) and adipose...