Deepak Vashishth
Overview
Explore the profile of Deepak Vashishth including associated specialties, affiliations and a list of published articles.
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Articles
95
Citations
2060
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Recent Articles
1.
Sihota P, Kumar S, Dhaliwal R, Uniyal P, Yadav R, Dhiman V, et al.
Bone
. 2024 Dec;
192():117375.
PMID: 39694129
Both trabecular and cortical bone undergo changes at multiple scales. We previously demonstrated the multi-scale changes in trabecular bone quality that contribute to bone fragility in type 2 diabetes (T2D)....
2.
Wang B, Dhaliwal R, Ewing S, Schwartz A, Vashishth D
J Clin Endocrinol Metab
. 2024 Nov;
PMID: 39512199
Context: Fracture risk is higher in type 2 diabetes (T2D) for a given bone mineral density (BMD) level. Increased oxidative stress in T2D induces diabetic complications and may affect T2D...
3.
Vashishth D, Dhaliwal R, Rubin M
Bone
. 2024 Oct;
190:117301.
PMID: 39442854
Advanced Glycation End-products (AGEs) are seen in long-lived proteins and were not expected to accumulate in the bone that turnovers and renews itself. Here, we provide a commentary on the...
4.
George W, Debopadhaya S, Stephen S, Botti B, Burr D, Vashishth D
Bone
. 2024 Oct;
190:117279.
PMID: 39393595
While it is known that excessive accumulation of fatigue damage from daily activities contributes to fracture, a model of bone failure under physiologically relevant multiaxial cyclic loading needs to be...
5.
Sroga G, Vashishth D
JBMR Plus
. 2024 Oct;
8(11):ziae110.
PMID: 39386996
Metabolic syndromes (eg, obesity, type 2 diabetes (T2D), atherosclerosis, and neurodegenerative diseases) and aging, they all have a strong component of carbonyl and reductive-oxidative (redox) stress. Reactive carbonyl (RCS) and...
6.
Brossfield A, McMahon D, Fernando J, Omeragic B, Majeed R, Agarwal S, et al.
J Clin Endocrinol Metab
. 2024 Oct;
PMID: 39376018
Context: Type 2 diabetes (T2D) patients have reduced bone turnover and increased fractures. Advanced glycation endproducts (AGEs) impair osteoblasts and are implicated in diabetic fractures. Pyridoxamine (PM) is a vitamin...
7.
Liu C, Cyphert E, Stephen S, Wang B, Morales A, Nixon J, et al.
J Bone Miner Res
. 2024 Sep;
39(11):1621-1632.
PMID: 39348436
Recent studies in mice have indicated that the gut microbiome can regulate bone tissue strength. However, prior work involved modifications to the gut microbiome in growing animals and it is...
8.
Wang B, Vashishth D
Bone
. 2023 Aug;
176:116880.
PMID: 37579812
Hyperglycemia and oxidative stress, enhanced in diabetes and aging, result in excessive accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone. AGEs/AGOES are considered to be "the missing...
9.
Korff C, Atkinson E, Adaway M, Klunk A, Wek R, Vashishth D, et al.
Calcif Tissue Int
. 2023 May;
113(1):110-125.
PMID: 37147466
The skeleton is a secretory organ, and the goal of some osteoporosis therapies is to maximize bone matrix output. Nmp4 encodes a novel transcription factor that regulates bone cell secretion...
10.
Pendyala M, Stephen S, Vashishth D, Blaber E, Chan D
Bone
. 2023 Apr;
172:116779.
PMID: 37100359
Hyaluronan, a glycosaminoglycan synthesized by three isoenzymes (Has1, Has2, Has3), is known to play a role in regulating bone turnover, remodeling, and mineralization, which in turn can affect bone quality...