Claudia Jomphe
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Explore the profile of Claudia Jomphe including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
161
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Recent Articles
1.
Song I, Chen G, Hayes S, Farrell C, Jomphe C, Gosselin N, et al.
J Pharmacokinet Pharmacodyn
. 2024 Sep;
51(6):887-904.
PMID: 39333337
Maribavir is approved for management of post-transplant cytomegalovirus (CMV) infections refractory and/or resistant to CMV therapies at a dose of 400 mg twice daily (BID). Population pharmacokinetic (PopPK) and exposure-response...
2.
Melch M, Lee J, Jomphe C, Robbie G
Clin Pharmacokinet
. 2023 Jan;
62(1):89-99.
PMID: 36633811
Background And Objective: Givosiran, approved for the treatment of acute hepatic porphyria (AHP), is the first subcutaneously administered RNAi therapeutic. This analysis was undertaken to describe the plasma pharmacokinetics (PK)...
3.
Lee S, Gosselin N, Jomphe C, McKeever K, Putnam W
Clin Pharmacol Drug Dev
. 2022 Jul;
11(11):1264-1272.
PMID: 35908210
Triheptanoin is an odd-carbon, medium-chain triglyceride consisting of three fatty acids with seven carbons each on a glycerol backbone, indicated for the treatment of adult and pediatric patients with long-chain...
4.
Marier J, Jomphe C, Peyret T, Wang Y
Clin Transl Sci
. 2021 Aug;
14(6):2497-2509.
PMID: 34402197
Teduglutide is a recombinant analog of human glucagon-like peptide-2 that regulates the functional and structural integrity of the cells lining the gastrointestinal tract. Teduglutide is approved for the treatment of...
5.
Wang Y, Jomphe C, Marier J, Martin P
J Clin Pharmacol
. 2020 Oct;
61(4):555-564.
PMID: 33091166
Elevated bradykinin levels are responsible for the development of clinical symptoms in patients with hereditary angioedema (HAE). Icatibant is a bradykinin type 2 receptor antagonist indicated for the acute treatment...
6.
Goel V, Gosselin N, Jomphe C, Zhang X, Marier J, Robbie G
Nucleic Acid Ther
. 2020 Mar;
30(3):143-152.
PMID: 32175804
Hereditary transthyretin-mediated amyloidosis is an inherited, rapidly progressive, life-threatening disease caused by mutated transthyretin (TTR) protein. Patisiran is a small interfering RNA (siRNA) formulated in a lipid nanoparticle that inhibits...
7.
Serrano A, Pare M, McIntosh F, Elmes S, Martino G, Jomphe C, et al.
Mol Pain
. 2010 Dec;
6:90.
PMID: 21143971
Background: The CCR2/CCL2 system has been identified as a regulator in the pathogenesis of neuropathy-induced pain. However, CCR2 target validation in analgesia and the mechanism underlying antinociception produced by CCR2...
8.
Jomphe C, Gabriac M, Hale T, Heroux L, Trudeau L, deBlois D, et al.
Basic Clin Pharmacol Toxicol
. 2007 Nov;
102(1):59-65.
PMID: 17983423
Chondroitin sulfate is referred as a symptomatic slow-acting drug for osteoarthritis because it improves articular function, and reduces joint swelling and effusion. In addition, chondroitin sulfate prevents joint space narrowing...
9.
St-Gelais F, Jomphe C, Trudeau L
J Psychiatry Neurosci
. 2006 Jul;
31(4):229-45.
PMID: 16862241
The peptide neurotensin has been studied for more than 30 years. Although it is widely distributed in the central and peripheral nervous systems, neurotensin has been more intensely studied with...
10.
Jomphe C, Tiberi M, Trudeau L
Neuropharmacology
. 2006 Jan;
50(5):595-605.
PMID: 16412480
Alternative splicing of the dopamine D2 receptor gene produces two distinct isoforms referred to as D2long (D2L) and D2short (D2S). In mesencephalic dopamine neurons, inhibition of the firing rate through...