Clarence R Hurt
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Explore the profile of Clarence R Hurt including associated specialties, affiliations and a list of published articles.
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10
Citations
118
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Recent Articles
1.
Fathman C, Yip L, Gomez-Martin D, Yu M, Seroogy C, Hurt C, et al.
Front Immunol
. 2022 Dec;
13:1046631.
PMID: 36569931
Regulatory T cells (T) normally maintain self-tolerance. T recognize "self" such that when they are not working properly, such as in autoimmunity, the immune system can attack and destroy one's...
2.
Soares L, Yip L, Hurt C, Fathman G
Crit Rev Immunol
. 2021 Jan;
40(3):185-193.
PMID: 33389883
We identified a druggable defect in IL-2 receptor (IL-2R) signaling by comparing the response of regulatory T cells (Tregs) of autoimmune disease patients to that of healthy controls. This defect...
3.
Reed J, Solas D, Kitaygorodskyy A, Freeman B, Ressler D, Phuong D, et al.
J Virol
. 2020 Nov;
95(3).
PMID: 33148797
Given the projected increase in multidrug-resistant HIV-1, there is an urgent need for development of antiretrovirals that act on virus life cycle stages not targeted by drugs currently in use....
4.
Broce S, Hensley L, Sato T, Lehrer-Graiwer J, Essrich C, Edwards K, et al.
Biol Direct
. 2016 May;
11:25.
PMID: 27179769
Background: Viral capsid assembly involves the oligomerization of the capsid nucleoprotein (NP), which is an essential step in viral replication and may represent a potential antiviral target. An in vitro...
5.
Spurgers K, Hurt C, Cohen J, Eccelston L, Lind C, Lingappa V, et al.
J Virol Methods
. 2013 Jun;
193(1):226-31.
PMID: 23764417
Venezuelan (VEEV), eastern, and western equine encephalitis viruses, members of the genus Alphavirus, are causative agents of debilitative and sometimes fatal encephalitis. Although human cases are rare, these viruses pose...
6.
Zhang C, Ibrahim P, Zhang J, Burton E, Habets G, Zhang Y, et al.
Proc Natl Acad Sci U S A
. 2013 Mar;
110(14):5689-94.
PMID: 23493555
Inflammation and cancer, two therapeutic areas historically addressed by separate drug discovery efforts, are now coupled in treatment approaches by a growing understanding of the dynamic molecular dialogues between immune...
7.
Lingappa U, Wu X, Macieik A, Yu S, Atuegbu A, Corpuz M, et al.
Proc Natl Acad Sci U S A
. 2013 Feb;
110(10):E861-8.
PMID: 23404707
We present an unconventional approach to antiviral drug discovery, which is used to identify potent small molecules against rabies virus. First, we conceptualized viral capsid assembly as occurring via a...
8.
Lingappa V, Hurt C, Garvey E
Curr Pharm Biotechnol
. 2012 Mar;
14(5):513-23.
PMID: 22429134
In general, drug discovery in the therapeutic field of infectious disease has a stellar track record. And yet, subsets of pathogens, for example many classes of viruses other than HIV,...
9.
Moos W, Hurt C, Morales G
Mol Divers
. 2009 Mar;
13(2):241-5.
PMID: 19255865
This short commentary takes a stroll through the early days of the field of combinatorial chemistry and molecular diversity. It offers a high-level perspective on the field's beginnings--and its future--as...
10.
Hurt C, Lin R, Rapoport H
J Org Chem
. 2001 Oct;
64(1):225-233.
PMID: 11674107
We report a new strategy for the enantiospecific synthesis of (R)-4-amino-5-oxo-1,3,4,5-tetrahydrobenz[cd]indole. This compound is an advanced intermediate which contains the tricyclic core of many of the tetracyclic ergot alkaloids. Our...