Prabhat C Goswami
Overview
Explore the profile of Prabhat C Goswami including associated specialties, affiliations and a list of published articles.
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70
Citations
1592
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Recent Articles
1.
Bayanbold K, Singhania M, Fath M, Searby C, Stolwijk J, Henrich J, et al.
Antioxidants (Basel)
. 2023 Nov;
12(11).
PMID: 38001858
The intracellular redox-active labile iron pool (LIP) is weakly chelated and available for integration into the iron metalloproteins that are involved in diverse cellular processes, including cancer cell-specific metabolic oxidative...
2.
Steers G, OLeary B, Du J, Wagner B, Carroll R, Domann F, et al.
Antioxidants (Basel)
. 2023 Sep;
12(9).
PMID: 37759986
Recent studies have demonstrated an important role for vitamin C in the epigenetic regulation of cancer-related genes via DNA demethylation by the ten-eleven translocation (TET) methylcytosine dioxygenase enzymes. DNA methyltransferase...
3.
OLeary B, Kalen A, Pope A, Goswami P, Cullen J
Radiat Res
. 2023 Sep;
200(5):444-455.
PMID: 37758045
Pharmacological ascorbate (P-AscH-, high dose, intravenous vitamin C) preferentially sensitizes human pancreas ductal adenocarcinoma (PDAC) cells to radiation-induced toxicity compared to non-tumorigenic epithelial cells. Radiation-induced G2-checkpoint activation contributes to the...
4.
Carroll R, Du J, OLeary B, Steers G, Goswami P, Buettner G, et al.
Free Radic Biol Med
. 2023 May;
204:108-117.
PMID: 37137343
Pharmacological ascorbate (P-AscH; high dose given intravenously) generates HO that is selectively cytotoxic to cancer compared to normal cells. The RAS-RAF-ERK1/2 is a major signaling pathway in cancers carrying RAS...
5.
Du J, Pope A, OLeary B, Wagner B, Goswami P, Buettner G, et al.
Sci Rep
. 2022 Dec;
12(1):22521.
PMID: 36581766
At pharmacological levels, ascorbate (P-AscH) acts as a pro-oxidant by generating HO, depleting ATP in sensitive cells leading to cell death. The aim of this study was to determine the...
6.
Callaghan C, Abukhiran I, Masaadeh A, Van Rheeden R, Kalen A, Rodman 3rd S, et al.
Int J Radiat Oncol Biol Phys
. 2022 Oct;
115(4):933-944.
PMID: 36228747
Purpose: Ataxia telangiectasia mutated kinase (ATM) inhibitors are potent radiosensitizers that regulate DNA damage responses and redox metabolism, but they have not been translated clinically because of the potential for...
7.
Ali M, Oliva C, Flor S, Goswami P, Griguer C
Free Radic Biol Med
. 2022 Apr;
185:25-35.
PMID: 35476930
Radiotherapy is an important treatment modality for glioblastoma (GBM), yet the initial effectiveness of radiotherapy is eventually lost due to the development of adaptive radioresistance during fractionated radiation therapy. Defining...
8.
Varmazyad M, Modi M, Kalen A, Sarsour E, Wagner B, Du J, et al.
Free Radic Biol Med
. 2021 Feb;
165:421-434.
PMID: 33561488
Dihydroartemisinin (DHA) is an FDA-approved antimalarial drug that has been repurposed for cancer therapy because of its preferential antiproliferative effects on cancer versus normal cells. Mitochondria represent an attractive target...
9.
Kloepping K, Kraus A, Hedlund D, Gnade C, Wagner B, McCormick M, et al.
PLoS One
. 2020 Dec;
15(12):e0244540.
PMID: 33378390
Despite dramatic improvements in outcomes arising from the introduction of targeted therapies and immunotherapies, metastatic melanoma is a highly resistant form of cancer with 5 year survival rates of <35%....
10.
Ali M, Oliva C, Noman A, Allen B, Goswami P, Zakharia Y, et al.
Cancers (Basel)
. 2020 Sep;
12(9).
PMID: 32899427
Ionizing radiation is a common and effective therapeutic option for the treatment of glioblastoma (GBM). Unfortunately, some GBMs are relatively radioresistant and patients have worse outcomes after radiation treatment. The...