Claire E Burkum
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Explore the profile of Claire E Burkum including associated specialties, affiliations and a list of published articles.
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11
Citations
202
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Recent Articles
1.
CD4 T cells specific for a latency-associated γ-herpesvirus epitope are polyfunctional and cytotoxic
Freeman M, Burkum C, Cookenham T, Roberts A, Lanzer K, Huston G, et al.
J Immunol
. 2014 Nov;
193(12):5827-34.
PMID: 25378595
The oncogenic γ-herpesviruses EBV and Kaposi sarcoma-associated herpesvirus are ubiquitous human pathogens that establish lifelong latent infections maintained by intermittent viral reactivation and reinfection. Effector CD4 T cells are critical...
2.
Freeman M, Roberts A, Burkum C, Woodland D, Blackman M
J Virol
. 2014 May;
88(14):7862-9.
PMID: 24789784
CD8 and CD4 T cells are each critically important for immune control of murine gammaherpesvirus 68 (γHV68) infection. In immunocompetent mice, acute γHV68 infection results in lifelong latency, but in...
3.
Freeman M, Burkum C, Lanzer K, Roberts A, Pinkevych M, Itakura A, et al.
J Autoimmun
. 2012 Dec;
42:71-9.
PMID: 23245703
Human herpesviruses establish lifelong latency. Viral recrudescence can lead to the development of cancers, immunoproliferative disorders, transplantation complications, and thrombocytopenia. Although platelet-specific autoantibodies have been reported in patients infected with...
4.
Freeman M, Burkum C, Jensen M, Woodland D, Blackman M
J Immunol
. 2012 Mar;
188(8):3812-9.
PMID: 22407914
The γ-herpesviruses are characterized by their ability to establish lifelong latency. Subsequent immune suppression leads to viral reactivation from latency and the onset of a variety of pathologies, including lymphoproliferative...
5.
Freeman M, Burkum C, Woodland D, Sun R, Wu T, Blackman M
J Immunol
. 2011 Dec;
188(3):1049-56.
PMID: 22198955
The human γ-herpesviruses EBV and Kaposi's sarcoma-associated herpesvirus establish lifelong latent infections, can reactivate in immunocompromised individuals, and are associated with the development of malignancies. Murine γ-herpesvirus-68 (γHV68), a rodent...
6.
Freeman M, Burkum C, Lanzer K, Jensen M, Ahmed M, Yager E, et al.
J Immunol
. 2011 Nov;
187(12):6180-4.
PMID: 22079983
CD4 T cells are essential for immune control of γ-herpesvirus latency. We previously identified a murine MHC class II-restricted epitope in γ-herpesvirus-68 gp150 (gp150(67-83)I-A(b)) that elicits CD4 T cells that...
7.
Freeman M, Burkum C, Yager E, Woodland D, Blackman M
J Virol
. 2011 Aug;
85(20):10920-5.
PMID: 21849446
The mechanisms by which gammaherpesviruses maintain latency are unclear. Here we used a murine gammaherpesvirus model to show that previously uninfected B cells in immunocompetent mice can acquire virus during...
8.
Kohlmeier J, Reiley W, Perona-Wright G, Freeman M, Yager E, Connor L, et al.
J Exp Med
. 2011 Jul;
208(8):1621-34.
PMID: 21788409
The development of T cell memory from naive precursors is influenced by molecular cues received during T cell activation and differentiation. In this study, we describe a novel role for...
9.
Yager E, Kim I, Freeman M, Lanzer K, Burkum C, Cookenham T, et al.
Immun Ageing
. 2010 Feb;
7:3.
PMID: 20181071
Background: Oncogenic gamma-herpesviruses establish life-long infections in their hosts and control of these latent infections is dependent on continual immune surveillance. Immune function declines with age, raising the possibility that...
10.
Yager E, Szaba F, Kummer L, Lanzer K, Burkum C, Smiley S, et al.
Viral Immunol
. 2009 Feb;
22(1):67-72.
PMID: 19210230
Herpesviruses are widely disseminated in the population and establish lifelong latency, which is associated with a variety of pathological consequences. A recent report showed that mice latently infected with either...