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Cinzia Allegrucci

Explore the profile of Cinzia Allegrucci including associated specialties, affiliations and a list of published articles. Areas
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Articles 46
Citations 1330
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Recent Articles
1.
Crowley D, Simpson L, Chatfield J, Forey T, Allegrucci C, Sang F, et al.
Cell Rep . 2025 Mar; 44(3):115396. PMID: 40057954
Francois Jacob proposed that evolutionary novelty arises through incremental tinkering with pre-existing genetic mechanisms. Vertebrate evolution was predicated on pluripotency, the ability of embryonic cells to form somatic germ layers...
2.
Ghannam S, Rutland C, Allegrucci C, Mather M, Alsaleem M, Bateman-Price T, et al.
J Microsc . 2024 Oct; 297(2):135-152. PMID: 39359124
Breast cancer (BC) is characterised by a high level of heterogeneity, which is influenced by the interaction of neoplastic cells with the tumour microenvironment. The diagnostic and prognostic role of...
3.
Ghannam S, Makhlouf S, Alsaleem M, Rutland C, Allegrucci C, Mongan N, et al.
Mod Pathol . 2024 Aug; 37(12):100607. PMID: 39216541
The tumor microenvironment plays a key role in tumor progression. The proportion of the stroma-to-tumor cells (stroma-tumor ratio [STR]) has a variable prognostic significance in breast cancer (BC) molecular classes....
4.
Patke R, Harris A, Woodcock C, Thompson R, Santos R, Kumari A, et al.
Neoplasia . 2024 Jul; 56:101032. PMID: 39033689
Prostate cancer (PCa) is the second most common cancer diagnosed in men. While radical prostatectomy and radiotherapy are often successful in treating localised disease, post-treatment recurrence is common. As the...
5.
Cardenas R, Zyoud A, McIntyre A, Alberio R, Mongan N, Allegrucci C
Stem Cell Res Ther . 2024 May; 15(1):128. PMID: 38693576
Background: Testicular germ cell tumours (TGCTs) represent a clinical challenge; they are most prevalent in young individuals and are triggered by molecular mechanisms that are not fully understood. The origin...
6.
Brown T, Rutland C, Choi K, Tse F, Peffers M, Mongan N, et al.
Front Cell Dev Biol . 2024 Mar; 12:1354606. PMID: 38455075
Prostate cancer (PCa) is a leading male malignancy worldwide, often progressing to bone metastasis, with limited curative options. Extracellular vesicles (EVs) have emerged as key players in cancer communication and...
7.
Atallah N, Haque M, Quinn C, Toss M, Makhlouf S, Ibrahim A, et al.
Eur J Cancer . 2023 Oct; 195:113371. PMID: 37897865
Background: Breast cancer (BC) expressing low levels of human epidermal growth factor receptor 2 (HER2 Low) is an emerging category that needs further refining. This study aims to provide a...
8.
Ghannam S, Rutland C, Allegrucci C, Mongan N, Rakha E
Histopathology . 2023 May; 83(3):376-393. PMID: 37232543
Background: Encapsulated papillary carcinoma (EPC) is surrounded by a thick fibrous capsule-like structure, which is interpreted as a thickened basement membrane (BM). This study aimed to describe the geometric characteristics...
9.
Lothion-Roy J, Haigh D, Harris A, Metzler V, Alsaleem M, Toss M, et al.
Front Genet . 2023 Feb; 13:1096071. PMID: 36733939
N-methyladenosine (mA) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the mA modification. These proteins, and the mA...
10.
Harris A, Metzler V, Lothion-Roy J, Varun D, Woodcock C, Haigh D, et al.
Front Endocrinol (Lausanne) . 2022 Oct; 13:1006101. PMID: 36263323
Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (e.g. abiraterone) or by antagonizing androgen receptor (AR) function (e.g. bicalutamide,...