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Andrew D Johnson

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Articles 277
Citations 22476
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Recent Articles
1.
Crowley D, Simpson L, Chatfield J, Forey T, Allegrucci C, Sang F, et al.
Cell Rep . 2025 Mar; 44(3):115396. PMID: 40057954
Francois Jacob proposed that evolutionary novelty arises through incremental tinkering with pre-existing genetic mechanisms. Vertebrate evolution was predicated on pluripotency, the ability of embryonic cells to form somatic germ layers...
2.
Little A, Zhao N, Mikhaylova A, Zhang A, Ling W, Thibord F, et al.
Genet Epidemiol . 2025 Jan; 49(1):e22610. PMID: 39812506
Integrating multi-omics data may help researchers understand the genetic underpinnings of complex traits and diseases. However, the best ways to integrate multi-omics data and use them to address pressing scientific...
3.
Jakubek Y, Ma X, Stilp A, Yu F, Bacon J, Wong J, et al.
Am J Hum Genet . 2025 Jan; 112(2):276-290. PMID: 39809269
Mosaic loss of Y (mLOY) is the most common somatic chromosomal alteration detected in human blood. The presence of mLOY is associated with altered blood cell counts and increased risk...
4.
Munsch G, Thibord F, Bezerra O, Brody J, van Hylckama Vlieg A, Gourhant L, et al.
medRxiv . 2024 Dec; PMID: 39677447
Venous thromboembolism (VT) is a frequent (annual incidence of 1 to 2 per 1,000) and potentially life-threatening (case-fatality rate up to 10%) disease. VT is associated with serious short-term and...
5.
Johnson A, Szczepiorkowski Z, Balogun R, Karam O, Nellis M, Schneiderman J, et al.
J Clin Apher . 2024 Oct; 39(5):e22146. PMID: 39420527
Apheresis is performed worldwide for an increasing number of indications. The development of common data elements (CDE) for apheresis related areas may facilitate conduct of new research, enhance quality initiatives...
6.
Huan T, Joehanes R, Rong J, Chen M, Mustafa R, Dehghan A, et al.
iScience . 2024 Oct; 27(10):110988. PMID: 39398240
MicroRNAs, crucial in regulating protein-coding gene expression, are implicated in various diseases. We performed a genome-wide association study of plasma miRNAs (ex-miRNAs) in 3,743 Framingham Heart Study (FHS) participants and...
7.
Li C, Malloy M, Ture S, Nieves-Lopez B, Thibord F, Johnson A, et al.
Res Pract Thromb Haemost . 2024 Sep; 8(6):102556. PMID: 39309233
Background: Our prior genome-wide association study of thrombin-induced platelet aggregation identified a G protein-coupled receptor kinase 5 (GRK5) noncoding variant (rs10886430-G) that is strongly associated with increased platelet reactivity to...
8.
Huffman J, Nicholas J, Hahn J, Heath A, Raffield L, Yanek L, et al.
Blood . 2024 Sep; 144(21):2248-2265. PMID: 39226462
Genetic studies have identified numerous regions associated with plasma fibrinogen levels in Europeans, yet missing heritability and limited inclusion of non-Europeans necessitates further studies with improved power and sensitivity. Compared...
9.
Kovbasyuk Z, Ramos-Cejudo J, Parekh A, Bubu O, Ayappa I, Varga A, et al.
J Am Heart Assoc . 2024 Jul; 13(15):e034079. PMID: 39056328
Background: Although related, the precise mechanisms linking obstructive sleep apnea (OSA) and cardiovascular disease (CVD) are unclear. Platelets are mediators of CVD risk and thrombosis and prior studies suggested associations...
10.
Banerjee M, Rowley J, Stubben C, Tolley N, Freson K, Nelson B, et al.
J Thromb Haemost . 2024 Jul; 22(10):2922-2934. PMID: 38969303
Genome-wide platelet transcriptomics is increasingly used to uncover new aspects of platelet biology and as a diagnostic and prognostic tool. Nevertheless, platelet isolation methods for transcriptomic studies are not standardized,...