Cina M Mack
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Explore the profile of Cina M Mack including associated specialties, affiliations and a list of published articles.
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10
Citations
88
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Recent Articles
1.
Mack C, Tsui-Bowen A, Smith A, Jensen K, Kodavanti P, Moser V, et al.
Neurotoxicology
. 2024 Jul;
103:256-265.
PMID: 38977203
The US EPA's Toxicity Forecaster (ToxCast) is a suite of high-throughput in vitro assays to screen environmental toxicants and predict potential toxicity of uncharacterized chemicals. This work examines the relevance...
2.
Johnstone A, Mack C, Valdez M, Shafer T, LoPachin R, Herr D, et al.
Toxicol In Vitro
. 2020 Sep;
69:104989.
PMID: 32882341
The Hard-Soft Acid and Base hypothesis can be used to predict the potential bio-reactivity (electrophilicity) of a chemical with intracellular proteins, resulting in neurotoxicity. Twelve chemicals predicted to be neurotoxic...
3.
Vassallo A, Chiappalone M, De Camargos Lopes R, Scelfo B, Novellino A, Defranchi E, et al.
Neurotoxicology
. 2016 Apr;
60:280-292.
PMID: 27036093
There is a need for methods to screen and prioritize chemicals for potential hazard, including neurotoxicity. Microelectrode array (MEA) systems enable simultaneous extracellular recordings from multiple sites in neural networks...
4.
Croom E, Shafer T, Evans M, Mundy W, Eklund C, Johnstone A, et al.
Toxicol Appl Pharmacol
. 2014 Dec;
283(1):9-19.
PMID: 25529470
Approaches for extrapolating in vitro toxicity testing results for prediction of human in vivo outcomes are needed. The purpose of this case study was to employ in vitro toxicokinetics and...
5.
Lantz S, Mack C, Wallace K, Key E, Shafer T, Casida J
Neurotoxicology
. 2014 Oct;
45:38-47.
PMID: 25268653
Glufosinate (GLF) at high levels in mammals causes convulsions and amnesia through a mechanism that is not completely understood. The structural similarity of GLF to glutamate (GLU) implicates the glutamatergic...
6.
Mack C, Lin B, Turner J, Johnstone A, Burgoon L, Shafer T
Neurotoxicology
. 2013 Dec;
40:75-85.
PMID: 24325902
Microelectrode arrays (MEAs) can be used to detect drug and chemical induced changes in neuronal network function and have been used for neurotoxicity screening. As a proof-of-concept, the current study...
7.
Gordon C, Gottipolu R, Kenyon E, Thomas R, Schladweiler M, Mack C, et al.
J Toxicol Environ Health A
. 2010 Jan;
73(4):301-18.
PMID: 20077299
Aging adults are a growing segment of the U.S. population and are likely to exhibit increased susceptibility to many environmental toxicants. However, there is little information on the susceptibility of...
8.
Mack C, Gordon C
J Toxicol Environ Health A
. 2007 Apr;
70(5):439-44.
PMID: 17454568
Organophosphate (OP) and carbamate (CB) insecticides inhibit cholinesterase (ChE) activity and induce acute hypothermia in adult rats. Studies showed that juveniles are generally more susceptible to neurotoxic insult than adults....
9.
Gordon C, Herr D, Gennings C, Graff J, McMurray M, Stork L, et al.
Toxicology
. 2005 Sep;
217(1):1-13.
PMID: 16182429
Most toxicity data are based on studies using single compounds. This study assessed if there is an interaction between mixtures of the anticholinesterase insecticides chlorpyrifos (CHP) and carbaryl (CAR) using...
10.
Gordon C, Mack C
J Toxicol Environ Health A
. 2003 Jan;
66(3):291-304.
PMID: 12521673
Diazinon is an organophosphate (OP)-based, anticholinesterase insecticide that irreversibly inhibits acetylcholinesterase activity and produces cholinergic stimulation in central nervous system (CNS) and peripheral tissues. Our laboratory has found that OPs...