Andrew F M Johnstone
Overview
Explore the profile of Andrew F M Johnstone including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
290
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0
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Recent Articles
1.
Valdez M, Valdez J, Freeborn D, Johnstone A, Kodavanti P
Toxicol Appl Pharmacol
. 2020 Sep;
408:115254.
PMID: 32991914
Ozone (O) is a widespread air pollutant that produces cardiovascular and pulmonary dysfunction possibly mediated by activation of central stress centers. Epidemiological data suggest that sedentary lifestyles may exacerbate responses...
2.
Johnstone A, Mack C, Valdez M, Shafer T, LoPachin R, Herr D, et al.
Toxicol In Vitro
. 2020 Sep;
69:104989.
PMID: 32882341
The Hard-Soft Acid and Base hypothesis can be used to predict the potential bio-reactivity (electrophilicity) of a chemical with intracellular proteins, resulting in neurotoxicity. Twelve chemicals predicted to be neurotoxic...
3.
Valdez M, Freeborn D, Valdez J, Johnstone A, J Snow S, Tennant A, et al.
Int J Mol Sci
. 2019 Dec;
20(24).
PMID: 31847143
Dietary supplementation with omega-3 and omega-6 fatty acids offer cardioprotection against air pollution, but these protections have not been established in the brain. We tested whether diets rich in omega-3...
4.
J Snow S, Phillips P, Ledbetter A, Johnstone A, Schladweiler M, Gordon C, et al.
J Toxicol Environ Health A
. 2019 Feb;
82(2):86-98.
PMID: 30755101
There is growing interest in understanding how maternal diet might affect the sensitivity of offspring to environmental exposures. Previous studies demonstrated that adult rat offspring (approximately 6-months-old) from dams given...
5.
Valdez J, Johnstone A, Richards J, Schmid J, Royland J, Kodavanti P
Int J Mol Sci
. 2018 Dec;
20(1).
PMID: 30577502
Oxidative stress (OS) contributes to the neurological and cardio/pulmonary effects caused by adverse metabolic states and air pollutants such as ozone (O₃). This study explores the interactive effects of O₃...
6.
Gordon C, Puckett E, Repasky E, Johnstone A
J Am Assoc Lab Anim Sci
. 2017 Mar;
56(2):173-176.
PMID: 28315647
Laboratories and vivariums typically are maintained at ambient temperatures of 20 to 24 °C, leading to cold stress in mice. When mice are inactive and sleeping during the light phase,...
7.
Johnstone A, Strickland J, Crofton K, Gennings C, Shafer T
Neurotoxicology
. 2016 May;
60:234-239.
PMID: 27177986
Pyrethroid insecticides exert their insecticidal and toxicological effects primarily by disrupting voltage-gated sodium channel (VGSC) function, resulting in altered neuronal excitability. Numerous studies of individual pyrethroids have characterized effects on...
8.
Vassallo A, Chiappalone M, De Camargos Lopes R, Scelfo B, Novellino A, Defranchi E, et al.
Neurotoxicology
. 2016 Apr;
60:280-292.
PMID: 27036093
There is a need for methods to screen and prioritize chemicals for potential hazard, including neurotoxicity. Microelectrode array (MEA) systems enable simultaneous extracellular recordings from multiple sites in neural networks...
9.
Gordon C, Phillips P, Johnstone A
Am J Physiol Renal Physiol
. 2015 Dec;
310(5):F426-31.
PMID: 26697983
Time-domain nuclear magnetic resonance (TD-NMR)-based measurement of body composition of rodents is an effective method to quickly and repeatedly measure proportions of fat, lean, and fluid without anesthesia. TD-NMR provides...
10.
Croom E, Shafer T, Evans M, Mundy W, Eklund C, Johnstone A, et al.
Toxicol Appl Pharmacol
. 2014 Dec;
283(1):9-19.
PMID: 25529470
Approaches for extrapolating in vitro toxicity testing results for prediction of human in vivo outcomes are needed. The purpose of this case study was to employ in vitro toxicokinetics and...