Chunqi Liu
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Explore the profile of Chunqi Liu including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
328
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Recent Articles
1.
Jie H, Wei J, Li Z, Yi M, Qian X, Li Y, et al.
Cancer Metab
. 2025 Feb;
13(1):10.
PMID: 39948566
Serine metabolism provides important metabolic intermediates that support the rapid proliferation of tumor cells. However, the role of serine metabolism in esophageal squamous cell carcinoma (ESCC) and the underlying mechanism...
2.
Su N, Tang R, Zhang Y, Ni J, Huang Y, Liu C, et al.
Front Pharmacol
. 2024 Dec;
15:1510220.
PMID: 39640479
Objectives: This study aimed to identify the risk factors for pancreatic cancer through machine learning. Methods: We investigated the relationships between different risk factors and pancreatic cancer using a real-world...
3.
Tao L, Zhou Y, Pan X, Luo Y, Qiu J, Zhou X, et al.
Nat Commun
. 2023 Nov;
14(1):7430.
PMID: 37973845
Poly (ADP-ribose) polymerase inhibitors (PARPi) are selectively active in ovarian cancer (OC) with homologous recombination (HR) deficiency (HRD) caused by mutations in BRCA1/2 and other DNA repair pathway members. We...
4.
Discovery and Optimization of Novel DHODH Inhibitors for the Treatment of Inflammatory Bowel Disease
Zhou X, Gou K, Xu J, Jian L, Luo Y, Li C, et al.
J Med Chem
. 2023 Oct;
66(21):14755-14786.
PMID: 37870434
As a key rate-limiting enzyme in the synthesis of pyrimidine nucleotides, human dihydroorotate dehydrogenase (DHODH) is considered a known target for the treatment of autoimmune diseases, including inflammatory bowel disease...
5.
Wang L, Wang X, Liu C, Xu W, Kuang W, Bu Q, et al.
Genomics Proteomics Bioinformatics
. 2023 May;
21(3):551-572.
PMID: 37209997
The expression of linear DNA sequence is precisely regulated by the three-dimensional (3D) architecture of chromatin. Morphine-induced aberrant gene networks of neurons have been extensively investigated; however, how morphine impacts...
6.
Wang X, Wang L, Luo M, Bu Q, Liu C, Jiang L, et al.
Cell Biol Toxicol
. 2021 Aug;
39(3):771-793.
PMID: 34458952
Clarithromycin (CLA) has been widely used in the treatment of bacterial infection. Research reveals the adverse effects on the central nervous system among patients receiving CLA treatment; whereas, a relevant...
7.
Li H, Xu W, Wang D, Wang L, Fang Q, Wan X, et al.
J Neurosci
. 2021 Jun;
41(31):6753-6774.
PMID: 34099513
The development, persistence and relapse of drug addiction require drug memory that generally develops with drug administration-paired contextual stimuli. Adult hippocampal neurogenesis (AHN) contributes to cocaine memory formation; however, the...
8.
Zhou Y, Tao L, Zhou X, Zuo Z, Gong J, Liu X, et al.
Cancer Metab
. 2021 May;
9(1):22.
PMID: 33971967
Human dihydroorotate dehydrogenase (DHODH) is a flavin-dependent mitochondrial enzyme catalyzing the fourth step in the de novo pyrimidine synthesis pathway. It is originally a target for the treatment of the...
9.
Liu C, Wang L, Liu X, Tan Y, Tao L, Xiao Y, et al.
Theranostics
. 2021 Jan;
11(6):2966-2986.
PMID: 33456583
Serine hydroxymethyltransferase 2 (SHMT2) plays a critical role in serine-glycine metabolism to drive cancer cell proliferation. However, the nonmetabolic function of SHMT2 in tumorigenesis, especially in human colorectal cancer (CRC)...
10.
Xu W, Li H, Wang L, Zhang J, Liu C, Wan X, et al.
Nat Commun
. 2020 Nov;
11(1):5962.
PMID: 33235205
The abuse potential of ketamine limits its clinical application, but the precise mechanism remains largely unclear. Here we discovered that ketamine significantly remodels the endocannabinoid-related lipidome and activates 2-arachidonoylglycerol (2-AG)...