Chunlai Chen
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Explore the profile of Chunlai Chen including associated specialties, affiliations and a list of published articles.
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66
Citations
915
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Recent Articles
1.
Liu W, Deng L, Wang M, Liu X, OuYang X, Wang Y, et al.
Mol Cell
. 2025 Feb;
85(5):929-947.e10.
PMID: 40015272
The PIWI-interacting RNA (piRNA) pathway plays a crucial role in protecting animal germ cells by repressing transposons. However, the mechanism of piRNA-guided heterochromatin formation and its relationship to transcriptional termination...
2.
Cheppali S, Li C, Xing W, Sun R, Yang M, Xue Y, et al.
Nat Commun
. 2025 Jan;
16(1):250.
PMID: 39747074
SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) proteins are the minimal machinery required for vesicle fusion in eukaryotes. Formation of a highly stable four-helix bundle consisting of SNARE motif...
3.
Miao Y, Cheng Y, Xia Y, Hei Y, Wang W, Dai Q, et al.
Nat Commun
. 2025 Jan;
16(1):74.
PMID: 39746928
Camera-based single-molecule techniques have emerged as crucial tools in revolutionizing the understanding of biochemical and cellular processes due to their ability to capture dynamic processes with high precision, high-throughput capabilities,...
4.
Li D, Zhang S, Lin S, Xing W, Yang Y, Zhu F, et al.
Nat Commun
. 2024 Dec;
15(1):10727.
PMID: 39737904
Exceptionally diverse type V CRISPR-Cas systems provide numerous RNA-guided nucleases as powerful tools for DNA manipulation. Two known Cas12e nucleases, DpbCas12e and PlmCas12e, are both effective in genome editing. However,...
5.
Ligand-Responsive Artificial Protein-Protein Communication for Field-Deployable Cell-Free Biosensing
Wang K, Liu S, Zhou S, Qileng A, Wang D, Liu Y, et al.
Angew Chem Int Ed Engl
. 2024 Nov;
64(4):e202416671.
PMID: 39558180
Natural protein-protein communications, such as those between transcription factors (TFs) and RNA polymerases/ribosomes, underpin cell-free biosensing systems operating on the transcription/translation (TXTL) paradigm. However, their deployment in field analysis is...
6.
Li C, Bian Y, Tang Y, Meng L, Yin P, Hong Y, et al.
Structure
. 2024 Nov;
33(1):62-77.e8.
PMID: 39541973
Nucleic acid and protein co-condensates exhibit diverse morphologies crucial for fundamental cellular processes. Despite many previous studies that advanced our understanding of this topic, several interesting biophysical questions regarding the...
7.
Zhou S, Miao Y, Qiu H, Yao Y, Wang W, Chen C
Commun Biol
. 2024 Oct;
7(1):1404.
PMID: 39468368
Long-term single-molecule fluorescence measurements are widely used powerful tools to study the conformational dynamics of biomolecules in real time to further elucidate their conformational dynamics. Typically, thousands or even more...
8.
Zhang W, Cheng L, Li K, Xie L, Ji J, Lei X, et al.
Nat Plants
. 2024 Jul;
10(8):1215-1230.
PMID: 39014153
Heterochromatic condensates (chromocenters) are critical for maintaining the silencing of heterochromatin. It is therefore puzzling that the presence of chromocenters is variable across plant species. Here we reveal that variations...
9.
Xing W, Li D, Wang W, Liu J, Chen C
Nucleic Acids Res
. 2024 Jul;
52(15):9014-9027.
PMID: 38994558
CasX (also known as Cas12e), a Class 2 CRISPR-Cas system, shows promise in genome editing due to its smaller size compared to the widely used Cas9 and Cas12a. Although the...
10.
Zhang S, Sun A, Qian J, Lin S, Xing W, Yang Y, et al.
Nature
. 2024 May;
630(8016):484-492.
PMID: 38811729
The CRISPR system is an adaptive immune system found in prokaryotes that defends host cells against the invasion of foreign DNA. As part of the ongoing struggle between phages and...