Chun-Chin Chen
Overview
Explore the profile of Chun-Chin Chen including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
17
Citations
506
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0
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Recent Articles
1.
Li Z, Fierstein S, Tanaka-Yano M, Frenis K, Chen C, Wang D, et al.
Leukemia
. 2024 Oct;
39(1):87-97.
PMID: 39354203
Acute myeloid leukemia (AML) shows variable clinical outcome. The normal hematopoietic cell of origin impacts the clinical behavior of AML, with AML from hematopoietic stem cells (HSCs) prone to chemotherapy...
2.
Chen C, Silberman R, Ma D, Perry J, Khalid D, Pikman Y, et al.
Leukemia
. 2024 Jan;
38(3):521-529.
PMID: 38245602
Constitutional trisomy 21 (T21) is a state of aneuploidy associated with high incidence of childhood acute myeloid leukemia (AML). T21-associated AML is preceded by transient abnormal myelopoiesis (TAM), which is...
3.
Feng Y, Lin Y, Chen C
PLoS One
. 2023 Aug;
18(8):e0290259.
PMID: 37616305
Obesity-related diseases have been on the rise, making it important to promote physical activity. Smart sports watches are popular among young people and can play a role in this regard....
4.
Marion W, Koppe T, Chen C, Wang D, Frenis K, Fierstein S, et al.
Leukemia
. 2023 Jun;
37(8):1698-1708.
PMID: 37391485
Many inherited bone marrow failure syndromes (IBMFSs) present a high risk of transformation to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). During transformation of IBMFSs, hematopoietic stem and progenitor...
5.
Chen B, Wang Y, Tubbs A, Zong D, Fowler F, Zolnerowich N, et al.
Elife
. 2021 Sep;
10.
PMID: 34477552
DNA double-strand break (DSB) repair by homologous recombination (HR) is thought to be restricted to the S- and G- phases of the cell cycle in part due to 53BP1 antagonizing...
6.
Chen C, Chen B, Wang Y, Curman P, Beilinson H, Brecht R, et al.
J Exp Med
. 2021 May;
218(8).
PMID: 34033676
A whole-genome CRISPR/Cas9 screen identified ATP2A2, the gene encoding the Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 2 protein, as being important for V(D)J recombination. SERCAs are ER transmembrane proteins that pump Ca2+...
7.
Yen W, Sharma R, Cols M, Lau C, Chaudhry A, Chowdhury P, et al.
Cell Rep
. 2019 May;
27(5):1472-1486.e5.
PMID: 31042474
The immunoglobulin heavy chain (Igh) locus features a dynamic chromatin landscape to promote class switch recombination (CSR), yet the mechanisms that regulate this landscape remain poorly understood. CHD4, a component...
8.
Chen C, Feng W, Lim P, Kass E, Jasin M
Annu Rev Cancer Biol
. 2018 Oct;
2:313-336.
PMID: 30345412
Germ-line and somatic mutations in genes that promote homology-directed repair (HDR), especially and , are frequently observed in several cancers, in particular, breast and ovary but also prostate and other...
9.
Chen C, Avdievich E, Zhang Y, Zhang Y, Wei K, Lee K, et al.
DNA Repair (Amst)
. 2017 Jul;
57:98-106.
PMID: 28711786
DNA double-strand breaks (DSBs) can be repaired through several mechanisms, including homologous recombination (HR). While HR between identical sequences is robust in mammalian cells, HR between diverged sequences is suppressed...
10.
Chen C, Kass E, Yen W, Ludwig T, Moynahan M, Chaudhuri J, et al.
Proc Natl Acad Sci U S A
. 2017 Jun;
114(29):7665-7670.
PMID: 28659469
BRCA1 is essential for homology-directed repair (HDR) of DNA double-strand breaks in part through antagonism of the nonhomologous end-joining factor 53BP1. The ATM kinase is involved in various aspects of...