Christopher Trotta
Overview
Explore the profile of Christopher Trotta including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
107
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Recent Articles
1.
Branstrom A, Cao L, Furia B, Trotta C, Santaguida M, Graci J, et al.
Front Oncol
. 2022 Feb;
12:832816.
PMID: 35223511
Blocking the pyrimidine nucleotide synthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH) results in the cell cycle arrest and/or differentiation of rapidly proliferating cells including activated lymphocytes, cancer cells, or virally...
2.
Luban J, Sattler R, Muhlberger E, Graci J, Cao L, Weetall M, et al.
Virus Res
. 2020 Nov;
292:198246.
PMID: 33249060
The coronavirus disease 2019 (COVID-19) pandemic has created an urgent need for therapeutics that inhibit the SARS-COV-2 virus and suppress the fulminant inflammation characteristic of advanced illness. Here, we describe...
3.
Luban J, Sattler R, Muhlberger E, Graci J, Cao L, Weetall M, et al.
bioRxiv
. 2020 Aug;
PMID: 32793904
The coronavirus disease 2019 (COVID-19) pandemic has created an urgent need for therapeutics that inhibit the SARS-CoV-2 virus and suppress the fulminant inflammation characteristic of advanced illness. Here, we describe...
4.
Cao L, Weetall M, Trotta C, Cintron K, Ma J, Kim M, et al.
Mol Cancer Ther
. 2018 Oct;
18(1):3-16.
PMID: 30352802
PTC299 was identified as an inhibitor of VEGFA mRNA translation in a phenotypic screen and evaluated in the clinic for treatment of solid tumors. To guide precision cancer treatment, we...
5.
Cao L, Weetall M, Bombard J, Qi H, Arasu T, Lennox W, et al.
PLoS One
. 2016 Dec;
11(12):e0168366.
PMID: 27992500
Current anti-VEGF (Vascular Endothelial Growth Factor A) therapies to treat various cancers indiscriminately block VEGF function in the patient resulting in the global loss of VEGF signaling which has been...
6.
Tsuboi T, Yamazaki R, Nobuta R, Ikeuchi K, Makino S, Ohtaki A, et al.
J Biol Chem
. 2015 May;
290(26):16021-30.
PMID: 25971974
The tRNA splicing endonuclease (Sen) complex is located on the mitochondrial outer membrane and splices precursor tRNAs in Saccharomyces cerevisiae. Here, we demonstrate that the Sen complex cleaves the mitochondria-localized...