Allan Jacobson
Overview
Explore the profile of Allan Jacobson including associated specialties, affiliations and a list of published articles.
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Articles
66
Citations
5012
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0
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Recent Articles
1.
Mangkalaphiban K, Ganesan R, Jacobson A
PLoS Genet
. 2024 Sep;
20(9):e1011392.
PMID: 39236083
Cytoplasmic poly(A)-binding protein (PABPC; Pab1 in yeast) is thought to be involved in multiple steps of post-transcriptional control, including translation initiation, translation termination, and mRNA decay. To understand both the...
2.
Wu C, Shazeeb M, Mangkalaphiban K, Han G, Peker A, Rentiya Z, et al.
Exp Neurol
. 2024 Aug;
380:114914.
PMID: 39106942
Neurofibromatosis type 1 (NF1) is a human genetic disorder caused by variants in the NF1 gene. Plexiform neurofibromas, one of many NF1 manifestations, are benign peripheral nerve sheath tumors occurring...
3.
Loveland A, Koh C, Ganesan R, Jacobson A, Korostelev A
Nature
. 2024 May;
630(8017):769-776.
PMID: 38718836
Angiogenin, an RNase-A-family protein, promotes angiogenesis and has been implicated in cancer, neurodegenerative diseases and epigenetic inheritance. After activation during cellular stress, angiogenin cleaves tRNAs at the anticodon loop, resulting...
4.
Mangkalaphiban K, Fu L, Du M, Thrasher K, Keeling K, Bedwell D, et al.
Nat Commun
. 2024 Mar;
15(1):2486.
PMID: 38509072
Protein synthesis terminates when a stop codon enters the ribosome's A-site. Although termination is efficient, stop codon readthrough can occur when a near-cognate tRNA outcompetes release factors during decoding. Seeking...
5.
Roeder R, Deibler S, Jacobson A, Lillie J, Rosbash M, Singer R, et al.
Mol Cell
. 2023 Jul;
83(13):2152-2154.
PMID: 37419086
No abstract available.
6.
Mangkalaphiban K, Ganesan R, Jacobson A
bioRxiv
. 2023 Jul;
PMID: 37398227
Cytoplasmic poly(A)-binding protein (PABPC; Pab1 in yeast) is thought to be involved in multiple steps of post-transcriptional control, including translation initiation, translation termination, and mRNA decay. To understand these roles...
7.
Ganesan R, Mangkalaphiban K, Baker R, He F, Jacobson A
RNA
. 2022 Oct;
28(12):1621-1642.
PMID: 36192133
Upf1, Upf2, and Upf3, the central regulators of nonsense-mediated mRNA decay (NMD), appear to exercise their NMD functions while bound to elongating ribosomes, and evidence for this conclusion is particularly...
8.
He F, Jacobson A
FEBS J
. 2022 Sep;
290(21):5057-5085.
PMID: 36098474
Decapping is the enzymatic removal of 5' cap structures from mRNAs in eukaryotic cells. Cap structures normally enhance mRNA translation and stability, and their excision commits an mRNA to complete...
9.
Wu C, Iyer S, Wolfe S, Jacobson A
J Hum Genet
. 2022 Aug;
67(11):661-668.
PMID: 35945271
Neurofibromatosis type 1 (NF1), one of the most common autosomal dominant genetic disorders, is caused by mutations in the NF1 gene. NF1 patients have a wide variety of manifestations with...
10.
He F, Wu C, Jacobson A
Elife
. 2022 May;
11.
PMID: 35604319
A single Dcp1-Dcp2 decapping enzyme targets diverse classes of yeast mRNAs for decapping-dependent 5' to 3' decay, but the molecular mechanisms controlling mRNA selectivity by the enzyme remain elusive. Through...