Christopher T Boughter
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Explore the profile of Christopher T Boughter including associated specialties, affiliations and a list of published articles.
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18
Citations
227
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Recent Articles
1.
Boughter C, Chatterjee B, Ohta Y, Gorga K, Blair C, Hill E, et al.
bioRxiv
. 2024 Jun;
PMID: 38903111
Declining sequencing costs coupled with the increasing availability of easy-to-use kits for the isolation of DNA and RNA transcripts from single cells have driven a rapid proliferation of studies centered...
2.
Boughter C, Meier-Schellersheim M
PLoS Comput Biol
. 2023 Oct;
19(10):e1011577.
PMID: 37862356
The adaptive immune system employs an array of receptors designed to respond with high specificity to pathogens or molecular aberrations faced by the host organism. Binding of these receptors to...
3.
Boughter C, Meier-Schellersheim M
Elife
. 2023 Oct;
12.
PMID: 37861280
T cells are critically important components of the adaptive immune system primarily responsible for identifying and responding to pathogenic challenges. This recognition of pathogens is driven by the interaction between...
4.
Borowska M, Boughter C, Bunker J, Guthmiller J, Wilson P, Roux B, et al.
Cell Rep
. 2023 Oct;
42(10):113190.
PMID: 37804505
To become specialized binders, antibodies undergo a process called affinity maturation to maximize their binding affinity. Despite this process, some antibodies retain low-affinity binding to diverse epitopes in a phenomenon...
5.
Jiang J, Boughter C, Ahmad J, Natarajan K, Boyd L, Meier-Schellersheim M, et al.
Commun Biol
. 2023 Sep;
6(1):953.
PMID: 37726484
The COVID-19 pandemic and SARS-CoV-2 variants have dramatically illustrated the need for a better understanding of antigen (epitope)-antibody (paratope) interactions. To gain insight into the immunogenic characteristics of epitopic sites...
6.
Jiang J, Boughter C, Ahmad J, Natarajan K, Boyd L, Meier-Schellersheim M, et al.
Res Sq
. 2023 Jun;
PMID: 37333174
The COVID-19 pandemic and SARS-CoV-2 variants have dramatically illustrated the need for a better understanding of antigen (epitope)-antibody (paratope) interactions. To gain insight into the immunogenic characteristics of epitopic sites...
7.
Jin H, Ladd N, Peev A, Swarbrick G, Cansler M, Null M, et al.
Sci Rep
. 2022 Dec;
12(1):22539.
PMID: 36581641
MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated in early effector responses to microbial infection. As a...
8.
Nandigrami P, Szczepaniak F, Boughter C, Dehez F, Chipot C, Roux B
J Phys Chem B
. 2022 Jul;
126(39):7510-7527.
PMID: 35787023
Atomic-level information is essential to explain the formation of specific protein complexes in terms of structure and dynamics. The set of Dpr and DIP proteins, which play a key role...
9.
Pittman J, Srivastava A, Boughter C, Venkata B, Zerweck J, Moore P, et al.
Biochemistry
. 2021 May;
60(36):2691-2703.
PMID: 34029056
Using atomic force microscopy (AFM) and nuclear magnetic resonance (NMR), we describe small Aβ40 oligomers, termed nanodroplet oligomers (NanDOs), which form rapidly and at Aβ40 concentrations too low for fibril...
10.
Boughter C, Borowska M, Guthmiller J, Bendelac A, Wilson P, Roux B, et al.
Elife
. 2020 Nov;
9.
PMID: 33169668
Antibodies are critical components of adaptive immunity, binding with high affinity to pathogenic epitopes. Antibodies undergo rigorous selection to achieve this high affinity, yet some maintain an additional basal level...