Christopher T A Lewis
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Explore the profile of Christopher T A Lewis including associated specialties, affiliations and a list of published articles.
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10
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18
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Recent Articles
1.
Increased cardiac myosin super-relaxation as an energy saving mechanism in hibernating grizzly bears
Van der Pijl R, Ma W, Lewis C, Haar L, Buhl A, Farman G, et al.
Mol Metab
. 2024 Dec;
92:102084.
PMID: 39694092
Aim: The aim of the present study was to define whether cardiac myosin contributes to energy conservation in the heart of hibernating mammals. Methods: Thin cardiac strips were isolated from...
2.
Van Den Berg M, Shi Z, Claassen W, Hooijman P, Lewis C, Andersen J, et al.
Sci Transl Med
. 2024 Jul;
16(758):eadg3894.
PMID: 39083588
Patients receiving mechanical ventilation in the intensive care unit (ICU) frequently develop contractile weakness of the diaphragm. Consequently, they may experience difficulty weaning from mechanical ventilation, which increases mortality and...
3.
Lewis C, Melhedegaard E, Ognjanovic M, Olsen M, Laitila J, Seaborne R, et al.
Elife
. 2024 May;
13.
PMID: 38752835
Hibernation is a period of metabolic suppression utilized by many small and large mammal species to survive during winter periods. As the underlying cellular and molecular mechanisms remain incompletely understood,...
4.
Lewis C, Melhedegaard E, Ognjanovic M, Olsen M, Laitila J, Seaborne R, et al.
bioRxiv
. 2023 Nov;
PMID: 38014200
Hibernation is a period of metabolic suppression utilized by many small and large mammal species to survive during winter periods. As the underlying cellular and molecular mechanisms remain incompletely understood,...
5.
Ochala J, Lewis C, Beck T, Iwamoto H, Hessel A, Campbell K, et al.
Am J Physiol Heart Circ Physiol
. 2023 Jul;
325(3):H585-H591.
PMID: 37505469
Dilated cardiomyopathy (DCM) is a naturally occurring heart failure condition in humans and dogs, notably characterized by a reduced contractility and ejection fraction. As the identification of its underlying cellular...
6.
Negoita F, Addinsall A, Hellberg K, Bringas C, Hafen P, Sermersheim T, et al.
Mol Metab
. 2023 Jun;
75:101761.
PMID: 37380024
Objective: The AMP-activated protein kinase (AMPK) gets activated in response to energetic stress such as contractions and plays a vital role in regulating various metabolic processes such as insulin-independent glucose...
7.
Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption
Lewis C, Tabrizian L, Nielsen J, Laitila J, Beck T, Olsen M, et al.
J Gen Physiol
. 2023 May;
155(7).
PMID: 37227464
It has recently been established that myosin, the molecular motor protein, is able to exist in two conformations in relaxed skeletal muscle. These conformations are known as the super-relaxed (SRX)...
8.
9.
Lewis C, Mascall K, Wilson H, Murray F, Kerr K, Gibson G, et al.
J Mol Cell Cardiol
. 2022 Nov;
174:25-37.
PMID: 36336008
Aortic valve stenosis is the most common valve disease in the western world. Central to the pathogenesis of this disease is the growth of new blood vessels (angiogenesis) within the...
10.
Lewis C, Ochala J
Physiology (Bethesda)
. 2022 Sep;
38(1).
PMID: 36067133
After years of intense research using structural, biological, and biochemical experimental procedures, it is clear that myosin molecules are essential for striated muscle contraction. However, this is just the tip...