Christopher Sie
Overview
Explore the profile of Christopher Sie including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
555
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Recent Articles
1.
Afzali A, Nirschl L, Sie C, Pfaller M, Ulianov O, Hassler T, et al.
Nature
. 2024 Feb;
627(8003):407-415.
PMID: 38383779
Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system, in which the water-channel protein AQP4 is the target antigen. The immunopathology in neuromyelitis optica is largely driven...
2.
Mitsdoerffer M, Aly L, Barz M, Engleitner T, Sie C, Delbridge C, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(34):e2206208119.
PMID: 35969754
Although glioblastoma multiforme (GBM) is not an invariably cold tumor, checkpoint inhibition has largely failed in GBM. In order to investigate T cell-intrinsic properties that contribute to the resistance of...
3.
Sie C, Kant R, Peter C, Muschaweckh A, Pfaller M, Nirschl L, et al.
J Exp Med
. 2022 Jul;
219(8).
PMID: 35819408
In certain instances, Th17 responses are associated with severe immunopathology. T cell-intrinsic mechanisms that restrict pathogenic effector functions have been described for type 1 and 2 responses but are less...
4.
Lutz K, Musumeci A, Sie C, Dursun E, Winheim E, Bagnoli J, et al.
Nat Commun
. 2022 Jun;
13(1):3456.
PMID: 35705536
Plasmacytoid and conventional dendritic cells (pDC and cDC) are generated from progenitor cells in the bone marrow and commitment to pDCs or cDC subtypes may occur in earlier and later...
5.
Mitsdoerffer M, Di Liberto G, Dotsch S, Sie C, Wagner I, Pfaller M, et al.
Brain
. 2021 Jul;
144(9):e83.
PMID: 34259834
No abstract available.
6.
Hiltensperger M, Beltran E, Kant R, Tyystjarvi S, Lepennetier G, Moreno H, et al.
Nat Immunol
. 2021 Jun;
22(7):880-892.
PMID: 34099917
Multidimensional single-cell analyses of T cells have fueled the debate about whether there is extensive plasticity or 'mixed' priming of helper T cell subsets in vivo. Here, we developed an...
7.
Mitsdoerffer M, Di Liberto G, Dotsch S, Sie C, Wagner I, Pfaller M, et al.
Brain
. 2021 Mar;
144(6):1697-1710.
PMID: 33693558
Meningeal B lymphocyte aggregates have been described in autopsy material of patients with chronic multiple sclerosis. The presence of meningeal B cell aggregates has been correlated with worse disease. However,...
8.
Sie C, Perez L, Kreutzfeldt M, Potthast M, Ohnmacht C, Merkler D, et al.
J Immunol
. 2019 Aug;
203(6):1417-1427.
PMID: 31399516
Homing of pathogenic CD4 T cells to the CNS is dependent on α4 integrins. However, it is uncertain whether α4 integrins are also required for the migration of dendritic cell...
9.
Knier B, Hiltensperger M, Sie C, Aly L, Lepennetier G, Engleitner T, et al.
Nat Immunol
. 2018 Oct;
19(12):1341-1351.
PMID: 30374128
Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) have been characterized in the context of malignancies. Here we show that PMN-MDSCs can restrain B cell accumulation during central nervous system (CNS) autoimmunity. Ly6G...
10.
Fischer H, Sie C, Schumann E, Witte A, Dressel R, van den Brandt J, et al.
J Immunol
. 2017 Jan;
198(5):1910-1920.
PMID: 28115529
T cell activation is an energy-demanding process fueled by increased glucose consumption and accompanied by upregulation of the insulin receptor (INSR). In this article, we report that silencing the INSR...