Christopher S Stach
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Explore the profile of Christopher S Stach including associated specialties, affiliations and a list of published articles.
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16
Citations
394
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Recent Articles
1.
Sychla A, Stach C, Roach S, Hayward A, Langlois R, Smanski M
bioRxiv
. 2024 Feb;
PMID: 38405907
Replication-incompetent single cycle infectious Influenza A Virus (sciIAV) has demonstrated utility as a research and vaccination platform. Protein-based therapeutics are increasingly attractive due to their high selectivity and potent efficacy...
2.
Stach C, McCann M, OBrien C, Le T, Somia N, Chen X, et al.
ACS Synth Biol
. 2019 Oct;
8(11):2524-2535.
PMID: 31596566
Chinese hamster ovary (CHO) cells are used for industrial production of protein-based therapeutics (i.e., "biologics"). Here we describe a method for combining systems-level kinetic models with a synthetic biology platform...
3.
OBrien S, Lee K, Fu H, Lee Z, Le T, Stach C, et al.
Biotechnol J
. 2018 Jul;
13(10):e1800226.
PMID: 30024101
For the biomanufacturing of protein biologics, establishing stable cell lines with high transgene transcription is critical for high productivity. Modern genome engineering tools can direct transgene insertion to a specified...
4.
Breshears L, Gillman A, Stach C, Schlievert P, Peterson M
PLoS One
. 2016 Jul;
11(7):e0158969.
PMID: 27414801
Secreted factors of Staphylococcus aureus can activate host signaling from the epidermal growth factor receptor (EGFR). The superantigen toxic shock syndrome toxin-1 (TSST-1) contributes to mucosal cytokine production through a...
5.
King J, Kulhankova K, Stach C, Vu B, Salgado-Pabon W
mSphere
. 2016 Jun;
1(3).
PMID: 27303750
Staphylococcus aureus diseases affect ~500,000 individuals per year in the United States. Worldwide, the USA100, USA200, USA400, and USA600 lineages cause many of the life-threatening S. aureus infections, such as...
6.
Stach C, Vu B, Merriman J, Herrera A, Cahill M, Schlievert P, et al.
PLoS One
. 2016 Apr;
11(4):e0154762.
PMID: 27124393
Background: Superantigens are indispensable virulence factors for Staphylococcus aureus in disease causation. Superantigens stimulate massive immune cell activation, leading to toxic shock syndrome (TSS) and contributing to other illnesses. However,...
7.
Herrera A, Vu B, Stach C, Merriman J, Horswill A, Salgado-Pabon W, et al.
Biochemistry
. 2016 Mar;
55(17):2510-7.
PMID: 27015018
β-Toxin is an important virulence factor of Staphylococcus aureus, contributing to colonization and development of disease [Salgado-Pabon, W., et al. (2014) J. Infect. Dis. 210, 784-792; Huseby, M. J., et...
8.
Stach C, Schlievert P
Methods Mol Biol
. 2015 Dec;
1396:67-71.
PMID: 26676037
Enhancement of susceptibility to lipopolysaccharide (LPS; endotoxin) is a defining characteristic of Staphylococcus aureus superantigens. At the time of this publication, there are 24 identified staphylococcal superantigens (SAgs), some of...
9.
Stach C, Vu B, Schlievert P
PLoS One
. 2015 Nov;
10(11):e0143341.
PMID: 26599862
Superantigens (SAgs) are important virulence factors in S. aureus. Recent studies identified their presence in animal coagulase-negative staphylococci (CNS). The emergence of human-associated SAg+ CNS would mark a prodigious shift...
10.
Vu B, Stach C, Kulhankova K, Salgado-Pabon W, Klingelhutz A, Schlievert P
mBio
. 2015 Feb;
6(2):e02554.
PMID: 25714716
Unlabelled: Excessive weight and obesity are associated with the development of diabetes mellitus type 2 (DMII) in humans. They also pose high risks of Staphylococcus aureus colonization and overt infections....