Christopher S Knauer
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Explore the profile of Christopher S Knauer including associated specialties, affiliations and a list of published articles.
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10
Citations
93
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Recent Articles
1.
McTier T, Chubb N, Curtis M, Hedges L, Inskeep G, Knauer C, et al.
Vet Parasitol
. 2016 Mar;
222:3-11.
PMID: 26961590
The novel isoxazoline ectoparasiticide, sarolaner, was identified during a lead optimization program for an orally-active compound with efficacy against fleas and ticks on dogs. The aim of the discovery program...
2.
Zhou X, Deng J, Hummel B, Woods D, Collard W, Hu S, et al.
J Parasitol
. 2014 Aug;
100(6):848-55.
PMID: 25116000
The objective of the current study was to establish an in vitro screen and a highly sensitive analytical assay to delineate key physicochemical properties that favor compound bioaccumulation in the...
3.
Woods D, Knauer C
Int J Parasitol
. 2010 May;
40(10):1177-81.
PMID: 20430031
Discovery of antiparasitic agents is a challenging process, requiring discovery of molecules with the ability to kill parasites but not their hosts. Customer preference is for fewer doses and ease...
4.
Knauer C, Campbell J, Chio C, Fitzgerald L
Naunyn Schmiedebergs Arch Pharmacol
. 2008 Dec;
379(5):461-71.
PMID: 19057895
The type 2 serotonin (5-HT(2)) receptor subfamily is known to couple to phosphoinositide hydrolysis (PI) and the subsequent mobilization of intracellular Ca(2+), as well as the release of arachidonic acid...
5.
Knauer C, Campbell J, Galvan B, Bowman C, Osgood S, Buist S, et al.
Eur J Pharmacol
. 2008 Jul;
591(1-3):136-41.
PMID: 18593577
An in vivo binding assay is characterized for [(3)H]M100907 binding to rat brain, as a measure of 5-HT(2A) receptor occupancy. Dose-response analyses were performed for various 5-HT(2A) antagonist reference agents,...
6.
Galatsis P, Yamagata K, Wendt J, Connolly C, Mickelson J, Milbank J, et al.
Bioorg Med Chem Lett
. 2007 Oct;
17(23):6525-8.
PMID: 17936624
We describe three novel regioisomeric series of aryl naphthyridine analogs, which are potent antagonists of the Class III GPCR mGlu5 receptor. The synthesis and in vitro and in vivo pharmacological...
7.
Corbett J, Rauckhorst M, Qian F, Hoffman R, Knauer C, Fitzgerald L
Bioorg Med Chem Lett
. 2007 Sep;
17(22):6250-6.
PMID: 17888659
Low nanomolar corticotropin releasing factor type-1 (CRF(1)) receptor antagonists containing unique indanylamines were identified from the heteroatom-linked pyrazine chemotype. The most potent indanylpyrazine had a K(i)=11+/-1 nM. The oxygen-linked pyrazinyl...
8.
Wendt J, Deeter S, Bove S, Knauer C, Brooker R, Augelli-Szafran C, et al.
Bioorg Med Chem Lett
. 2007 Aug;
17(19):5396-9.
PMID: 17723296
A novel series of potent 2-aryl pyrido[2,3-d]pyrimidine mGlu5 receptor antagonists are described. The synthesis and pharmacological activities of these analogs are discussed.
9.
Milbank J, Knauer C, Augelli-Szafran C, Sakkab-Tan A, Lin K, Yamagata K, et al.
Bioorg Med Chem Lett
. 2007 Jun;
17(16):4415-8.
PMID: 17590335
Rational replacement of the alkyne linker of mGluR5 antagonist MPEP gave 7-arylquinolines. SAR optimization gave an orally active compound with high affinity for the MPEP binding site.
10.
Ennis M, Hoffman R, Ghazal N, Olson R, Knauer C, Chio C, et al.
Bioorg Med Chem Lett
. 2003 Jun;
13(14):2369-72.
PMID: 12824036
The design and synthesis of the novel 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole 5 is described. This azepinoindole has excellent affinity for 5-HT(2C) (K(i) 4.8 nM) and modest selectivity over 5-HT(2A) ( approximately 4-fold). Several...