Synthesis and SAR Comparison of Regioisomeric Aryl Naphthyridines As Potent MGlu5 Receptor Antagonists

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2007 Oct 16

PMID 17936624

Citations 8

Authors

Paul Galatsis

Koji Yamagata

John A Wendt

Cleo J Connolly

John W Mickelson

Jared B J Milbank

Susan E Bove

Christopher S Knauer

Rachel M Brooker

Corinne E Augelli-Szafran

Roy D Schwarz

Jack J Kinsora

Kenneth S Kilgore

Affiliations

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Abstract

We describe three novel regioisomeric series of aryl naphthyridine analogs, which are potent antagonists of the Class III GPCR mGlu5 receptor. The synthesis and in vitro and in vivo pharmacological activities of these analogs are discussed.

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