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Christopher S Carlson

Explore the profile of Christopher S Carlson including associated specialties, affiliations and a list of published articles. Areas
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Articles 129
Citations 8250
Followers 0
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Recent Articles
1.
Guo B, Cai Y, Kim D, Smit R, Wang Z, Iyer K, et al.
medRxiv . 2025 Mar; PMID: 40034751
Polygenic risk scores (PRS) hold prognostic value for identifying individuals at higher risk of type 2 diabetes (T2D). However, further characterization is needed to understand the generalizability of T2D PRS...
2.
Zhang X, Brody J, Graff M, Highland H, Chami N, Xu H, et al.
medRxiv . 2023 Sep; PMID: 37662265
Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European...
3.
Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, et al.
medRxiv . 2023 Jul; PMID: 37461624
Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in non-European ancestry groups in genome-wide association studies (GWAS). We constructed and analyzed a multi-ancestry GWAS dataset...
4.
Highland H, Wojcik G, Graff M, Nishimura K, Hodonsky C, Baldassari A, et al.
Am J Hum Genet . 2022 Mar; 109(4):669-679. PMID: 35263625
One mechanism by which genetic factors influence complex traits and diseases is altering gene expression. Direct measurement of gene expression in relevant tissues is rarely tenable; however, genetically regulated gene...
5.
Downie C, Dimos S, Bien S, Hu Y, Darst B, Polfus L, et al.
Diabetologia . 2021 Dec; 65(3):477-489. PMID: 34951656
Aims/hypothesis: Type 2 diabetes is a growing global public health challenge. Investigating quantitative traits, including fasting glucose, fasting insulin and HbA, that serve as early markers of type 2 diabetes...
6.
Hu Y, Graff M, Haessler J, Buyske S, Bien S, Tao R, et al.
PLoS Genet . 2020 Apr; 16(3):e1008684. PMID: 32226016
Lipid levels are important markers for the development of cardio-metabolic diseases. Although hundreds of associated loci have been identified through genetic association studies, the contribution of genetic factors to variation...
7.
Bien S, Su Y, Conti D, Harrison T, Qu C, Guo X, et al.
Hum Genet . 2019 Jun; 138(7):789-791. PMID: 31254090
Every author has erroneously been assigned to the affiliation "62". The affiliation 62 belongs to the author Graham Casey.
8.
Wojcik G, Graff M, Nishimura K, Tao R, Haessler J, Gignoux C, et al.
Nature . 2019 Jun; 570(7762):514-518. PMID: 31217584
Genome-wide association studies (GWAS) have laid the foundation for investigations into the biology of complex traits, drug development and clinical guidelines. However, the majority of discovery efforts are based on...
9.
Lin B, Nadkarni G, Tao R, Graff M, Fornage M, Buyske S, et al.
Front Genet . 2019 Jun; 10:494. PMID: 31178898
Background: Chronic kidney disease (CKD) is common and disproportionally burdens United States ethnic minorities. Its genetic determinants may differ by disease severity and clinical stages. To uncover genetic factors associated...
10.
Bien S, Su Y, Conti D, Harrison T, Qu C, Guo X, et al.
Hum Genet . 2019 Mar; 138(4):307-326. PMID: 30820706
Genome-wide association studies have reported 56 independently associated colorectal cancer (CRC) risk variants, most of which are non-coding and believed to exert their effects by modulating gene expression. The computational...