Martha L Slattery
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Explore the profile of Martha L Slattery including associated specialties, affiliations and a list of published articles.
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363
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11919
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Recent Articles
1.
Chen Z, Guo X, Tao R, Huyghe J, Law P, Fernandez-Rozadilla C, et al.
Nat Commun
. 2024 Apr;
15(1):3557.
PMID: 38670944
Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We...
2.
Thomas M, Su Y, Rosenthal E, Sakoda L, Schmit S, Timofeeva M, et al.
Nat Commun
. 2023 Oct;
14(1):6147.
PMID: 37783704
Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry...
3.
Aglago E, Kim A, Lin Y, Qu C, Evangelou M, Ren Y, et al.
Cancer Res
. 2023 May;
83(15):2572-2583.
PMID: 37249599
Significance: This gene-environment interaction analysis revealed a genetic locus in FMN1/GREM1 that interacts with body mass index in colorectal cancer risk, suggesting potential implications for precision prevention strategies.
4.
Thomas M, Su Y, Rosenthal E, Sakoda L, Schmit S, Timofeeva M, et al.
medRxiv
. 2023 Feb;
PMID: 36789420
Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry...
5.
Ugai T, Haruki K, Harrison T, Cao Y, Qu C, Chan A, et al.
Am J Gastroenterol
. 2023 Jan;
118(4):712-726.
PMID: 36707929
Introduction: Early-onset colorectal cancer diagnosed before the age of 50 years has been increasing. Likely reflecting the pathogenic role of the intestinal microbiome, which gradually changes across the entire colorectal...
6.
Ugai T, Akimoto N, Haruki K, Harrison T, Cao Y, Qu C, et al.
J Gastroenterol
. 2023 Jan;
58(3):229-245.
PMID: 36648535
Background: The pathogenic effect of colorectal tumor molecular features may be influenced by several factors, including those related to microbiota, inflammation, metabolism, and epigenetics, which may change along colorectal segments....
7.
Su Y, Sakoda L, Jeon J, Thomas M, Lin Y, Schneider J, et al.
Cancer Epidemiol Biomarkers Prev
. 2023 Jan;
32(3):353-362.
PMID: 36622766
Background: Polygenic risk scores (PRS) which summarize individuals' genetic risk profile may enhance targeted colorectal cancer screening. A critical step towards clinical implementation is rigorous external validations in large community-based...
8.
Carreras-Torres R, Kim A, Lin Y, Diez-Obrero V, Bien S, Qu C, et al.
Cancer Epidemiol Biomarkers Prev
. 2022 Dec;
32(3):315-328.
PMID: 36576985
Background: Tobacco smoking is an established risk factor for colorectal cancer. However, genetically defined population subgroups may have increased susceptibility to smoking-related effects on colorectal cancer. Methods: A genome-wide interaction...
9.
Haas C, Su Y, Petersen P, Wang X, Bien S, Lin Y, et al.
Sci Rep
. 2022 Nov;
12(1):18852.
PMID: 36344807
Observational studies have shown higher folate consumption to be associated with lower risk of colorectal cancer (CRC). Understanding whether and how genetic risk factors interact with folate could further elucidate...
10.
Barfield R, Qu C, Steinfelder R, Zeng C, Harrison T, Brezina S, et al.
Sci Rep
. 2022 Jun;
12(1):10207.
PMID: 35715570
Colorectal cancer (CRC) is a heterogeneous disease with evidence of distinct tumor types that develop through different somatically altered pathways. To better understand the impact of the host genome on...