Christopher S Brower
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Explore the profile of Christopher S Brower including associated specialties, affiliations and a list of published articles.
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19
Citations
625
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Recent Articles
1.
Kasu Y, Arva A, Johnson J, Sajan C, Manzano J, Hennes A, et al.
iScience
. 2022 May;
25(5):104273.
PMID: 35542047
Neurodegeneration is associated with the aggregation of proteins bearing solvent-exposed hydrophobicity as a result of their misfolding and/or proteolytic cleavage. An understanding of the cellular protein quality control mechanisms which...
2.
Arva A, Kasu Y, Duncan J, Alkhatatbeh M, Brower C
Proc Natl Acad Sci U S A
. 2021 Jan;
118(1).
PMID: 33443146
The Ligand of Ate1 (Liat1) is a protein of unknown function that was originally discovered through its interaction with arginyl-tRNA protein transferase 1 (Ate1), a component of the Arg/N-degron pathway...
3.
Kechko O, Petrushanko I, Brower C, Adzhubei A, Moskalev A, Piatkov K, et al.
Aging (Albany NY)
. 2019 Aug;
11(16):6134-6152.
PMID: 31446431
Alzheimer's disease (AD) is accompanied by the dysfunction of intracellular protein homeostasis systems, in particular the ubiquitin-proteasome system (UPS). Beta-amyloid peptide (Aβ), which is involved in the processes of neurodegeneration...
4.
Kasu Y, Alemu S, Lamari A, Loew N, Brower C
Mol Cell Biol
. 2018 Jul;
38(19).
PMID: 29987190
Fragments of the TAR DNA-binding protein 43 (TDP43) are major components of intracellular aggregates associated with amyotrophic lateral sclerosis and frontotemporal dementia. A variety of C-terminal fragments (CTFs) exist, with...
5.
Wadas B, Piatkov K, Brower C, Varshavsky A
J Biol Chem
. 2016 Aug;
291(40):20976-20992.
PMID: 27510035
N-terminal arginylation (Nt-arginylation) of proteins is mediated by the Ate1 arginyltransferase (R-transferase), a component of the Arg/N-end rule pathway. This proteolytic system recognizes proteins containing N-terminal degradation signals called N-degrons,...
6.
Liu Y, Liu C, Chang Z, Wadas B, Brower C, Song Z, et al.
J Biol Chem
. 2016 Feb;
291(14):7426-38.
PMID: 26858254
The Ate1 arginyltransferase (R-transferase) is a component of the N-end rule pathway, which recognizes proteins containing N-terminal degradation signals called N-degrons, polyubiquitylates these proteins, and thereby causes their degradation by...
7.
Brower C, Rosen C, Jones R, Wadas B, Piatkov K, Varshavsky A
Proc Natl Acad Sci U S A
. 2014 Nov;
111(46):E4936-45.
PMID: 25369936
The arginyltransferase Ate1 is a component of the N-end rule pathway, which recognizes proteins containing N-terminal degradation signals called N-degrons, polyubiquitylates these proteins, and thereby causes their degradation by the...
8.
Brower C, Piatkov K, Varshavsky A
Mol Cell
. 2013 Mar;
50(2):161-71.
PMID: 23499006
Protein aggregates are a common feature of neurodegenerative syndromes. Specific protein fragments were found to be aggregated in disorders including Alzheimer's disease, amyotrophic lateral sclerosis, and Parkinson's disease. Here, we...
9.
Piatkov K, Brower C, Varshavsky A
Proc Natl Acad Sci U S A
. 2012 Jun;
109(27):E1839-47.
PMID: 22670058
In the course of apoptosis, activated caspases cleave ∼500 to ∼1,000 different proteins in a mammalian cell. The dynamics of apoptosis involve a number of previously identified, caspase-generated proapoptotic protein...
10.
Brower C, Veiga L, Jones R, Varshavsky A
J Biol Chem
. 2010 Apr;
285(22):17218-34.
PMID: 20356838
Our study of the mouse Ate1 arginyltransferase, a component of the N-end rule pathway, has shown that Ate1 pre-mRNA is produced from a bidirectional promoter that also expresses, in the...