Christopher R Gignoux
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Explore the profile of Christopher R Gignoux including associated specialties, affiliations and a list of published articles.
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113
Citations
5331
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Recent Articles
21.
Kachuri L, Mak A, Hu D, Eng C, Huntsman S, Elhawary J, et al.
Nat Genet
. 2023 May;
55(6):952-963.
PMID: 37231098
We explored ancestry-related differences in the genetic architecture of whole-blood gene expression using whole-genome and RNA sequencing data from 2,733 African Americans, Puerto Ricans and Mexican Americans. We found that...
22.
Chan T, Rui X, Conti D, Fornage M, Graff M, Haessler J, et al.
bioRxiv
. 2023 May;
PMID: 37131817
The heritability explained by local ancestry markers in an admixed population provides crucial insight into the genetic architecture of a complex disease or trait. Estimation of can be susceptible to...
23.
Cullina S, Wojcik G, Shemirani R, Klarin D, Gorman B, Sorokin E, et al.
medRxiv
. 2023 Apr;
PMID: 37034679
Peripheral artery disease (PAD) is a form of atherosclerotic cardiovascular disease, affecting ∼8 million Americans, and is known to have racial and ethnic disparities. PAD has been reported to have...
24.
Marker K, Mathias R, Gignoux C
J Allergy Clin Immunol
. 2023 Mar;
151(5):1244-1245.
PMID: 36963618
No abstract available.
25.
Zhou W, Kanai M, Wu K, Rasheed H, Tsuo K, Hirbo J, et al.
Cell Genom
. 2023 Feb;
2(10):100192.
PMID: 36777996
Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic loci across a range of human diseases and traits. However, most biobanks are primarily composed of individuals of European ancestry....
26.
Brice A, Vanderlinden L, Marker K, Mayer D, Lin M, Rafaels N, et al.
Int J Environ Res Public Health
. 2023 Feb;
20(3).
PMID: 36767733
Over 6.37 million people have died from COVID-19 worldwide, but factors influencing COVID-19-related mortality remain understudied. We aimed to describe and identify risk factors for COVID-19 mortality in the Colorado...
27.
Konigsberg I, Barnes B, Campbell M, Davidson E, Zhen Y, Pallisard O, et al.
Commun Med (Lond)
. 2023 Feb;
1(1):42.
PMID: 36750622
Background: Since the onset of the SARS-CoV-2 pandemic, most clinical testing has focused on RT-PCR. Host epigenome manipulation post coronavirus infection suggests that DNA methylation signatures may differentiate patients with...
28.
Shemirani R, Belbin G, Burghardt K, Lerman K, Avery C, Kenny E, et al.
Pac Symp Biocomput
. 2022 Dec;
28:121-132.
PMID: 36540970
Groups of distantly related individuals who share a short segment of their genome identical-by-descent (IBD) can provide insights about rare traits and diseases in massive biobanks using IBD mapping. Clustering...
29.
Wade K, Tisa S, Barrington C, Henriksen J, Crooks K, Gignoux C, et al.
PLoS One
. 2022 Oct;
17(10):e0274050.
PMID: 36194597
Since the initial reported discovery of SARS-CoV-2 in late 2019, genomic surveillance has been an important tool to understand its transmission and evolution. Here, we sought to describe the underlying...
30.
Redondo M, Gignoux C, Dabelea D, Hagopian W, Onengut-Gumuscu S, Oram R, et al.
Lancet Diabetes Endocrinol
. 2022 Jun;
10(8):597-608.
PMID: 35724677
Over 75 genetic loci within and outside of the HLA region influence type 1 diabetes risk. Genetic risk scores (GRS), which facilitate the integration of complex genetic information, have been...