L Keoki Williams
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Explore the profile of L Keoki Williams including associated specialties, affiliations and a list of published articles.
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165
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5410
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Recent Articles
1.
Venkateswaran V, She R, Gardell S, Luzum J, Gupta R, Zhang K, et al.
ESC Heart Fail
. 2025 Mar;
PMID: 40064034
Aims: Plasma metabolites are prognostic in heart failure with reduced ejection fraction (HFrEF), with citric acid cycle metabolites linked to ejection fraction (EF) changes. We investigated these mechanisms in a...
2.
Henry A, Mo X, Finan C, Chaffin M, Speed D, Issa H, et al.
Nat Genet
. 2025 Mar;
PMID: 40038546
Heart failure (HF) is a major contributor to global morbidity and mortality. While distinct clinical subtypes, defined by etiology and left ventricular ejection fraction, are well recognized, their genetic determinants...
3.
Venkateswaran V, She R, Gui H, Luzum J, Bryson T, Malouf Z, et al.
Front Cardiovasc Med
. 2024 Jul;
11:1409340.
PMID: 39045004
Background: Heart failure with reduced ejection fraction (HFrEF) remains a significant public health issue, with the disease advancing despite neurohormonal antagonism. Energetic dysfunction is a likely contributor to residual disease...
4.
Keener R, Chhetri S, Connelly C, Taub M, Conomos M, Weinstock J, et al.
Nat Commun
. 2024 May;
15(1):4417.
PMID: 38789417
Genome-wide association studies (GWAS) have become well-powered to detect loci associated with telomere length. However, no prior work has validated genes nominated by GWAS to examine their role in telomere...
5.
Varshney A, Manickam N, Orchard P, Tovar A, Ventresca C, Zhang Z, et al.
bioRxiv
. 2024 Jan;
PMID: 38168419
Skeletal muscle, the largest human organ by weight, is relevant in several polygenic metabolic traits and diseases including type 2 diabetes (T2D). Identifying genetic mechanisms underlying these traits requires pinpointing...
6.
Luzum J, Campos-Staffico A, Li J, She R, Gui H, Peterson E, et al.
Genes (Basel)
. 2023 Nov;
14(11).
PMID: 38002962
In patients with heart failure with reduced ejection fraction (HFrEF), individual responses to beta-blockers vary. Candidate gene pharmacogenetic studies yielded significant but inconsistent results, and they may have missed important...
7.
Budu-Aggrey A, Kilanowski A, Sobczyk M, Shringarpure S, Mitchell R, Reis K, et al.
Nat Commun
. 2023 Oct;
14(1):6172.
PMID: 37794016
Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS...
8.
Gui H, Tang W, Francke S, Li J, She R, Bazeley P, et al.
Circ Heart Fail
. 2023 Sep;
16(9):e010438.
PMID: 37725680
Background: Heart failure remains a global health burden, and patients hospitalized are particularly at risk, but genetic associates for subsequent death or rehospitalization are still lacking. Methods: The genetic substudy...
9.
Wu B, Yee S, Xiao S, Xu F, Sridhar S, Yang M, et al.
Diabetes Care
. 2023 Aug;
47(2):208-215.
PMID: 37639712
Objective: Metformin is the most common treatment for type 2 diabetes (T2D). However, there have been no pharmacogenomic studies for T2D in which a population of color was used in...
10.
Kachuri L, Mak A, Hu D, Eng C, Huntsman S, Elhawary J, et al.
Nat Genet
. 2023 May;
55(6):952-963.
PMID: 37231098
We explored ancestry-related differences in the genetic architecture of whole-blood gene expression using whole-genome and RNA sequencing data from 2,733 African Americans, Puerto Ricans and Mexican Americans. We found that...