Christopher R Gignoux
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Explore the profile of Christopher R Gignoux including associated specialties, affiliations and a list of published articles.
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113
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5331
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Recent Articles
11.
Williams C, OConnell J, Freyman W, Gignoux C, Ramachandran S, Williams A
bioRxiv
. 2024 May;
PMID: 38766004
Haplotype phasing, the process of determining which genetic variants are physically located on the same chromosome, is crucial for various genetic analyses. In this study, we first benchmark SHAPEIT and...
12.
Wiley L, Shortt J, Roberts E, Lowery J, Kudron E, Lin M, et al.
Am J Hum Genet
. 2024 Jan;
111(1):11-23.
PMID: 38181729
Precision medicine initiatives across the globe have led to a revolution of repositories linking large-scale genomic data with electronic health records, enabling genomic analyses across the entire phenome. Many of...
13.
Arehart C, Sterrett J, Garris R, Quispe-Pilco R, Gignoux C, Evans L, et al.
mSystems
. 2023 Dec;
9(1):e0067723.
PMID: 38095449
Inflammatory bowel disease (IBD) is characterized by complex etiology and a disrupted colonic ecosystem. We provide a framework for the analysis of multi-omic data, which we apply to study the...
14.
Maldonado B, Pique D, Kaplan R, Claw K, Gignoux C
J Community Genet
. 2023 Nov;
14(6):543-553.
PMID: 37962783
Genome-wide association studies (GWAS) have allowed the identification of disease-associated variants, which can be leveraged to build polygenic scores (PGSs). Even though PGSs can be a valuable tool in personalized...
15.
Chan T, Rui X, Conti D, Fornage M, Graff M, Haessler J, et al.
Am J Hum Genet
. 2023 Oct;
110(11):1853-1862.
PMID: 37875120
The heritability explained by local ancestry markers in an admixed population (h) provides crucial insight into the genetic architecture of a complex disease or trait. Estimation of h can be...
16.
Sohail M, Palma-Martinez M, Chong A, Quinto-Cortes C, Barberena-Jonas C, Medina-Munoz S, et al.
Nature
. 2023 Oct;
622(7984):775-783.
PMID: 37821706
Latin America continues to be severely underrepresented in genomics research, and fine-scale genetic histories and complex trait architectures remain hidden owing to insufficient data. To fill this gap, the Mexican...
17.
Anwar M, Graff M, Highland H, Smit R, Wang Z, Buchanan V, et al.
Hum Genet
. 2023 Sep;
142(10):1477-1489.
PMID: 37658231
Inadequate representation of non-European ancestry populations in genome-wide association studies (GWAS) has limited opportunities to isolate functional variants. Fine-mapping in multi-ancestry populations should improve the efficiency of prioritizing variants for...
18.
Lee M, Dimos S, Raffield L, Wang Z, Ballou A, Downie C, et al.
Open Heart
. 2023 Aug;
10(2).
PMID: 37648373
Introduction: The independent and causal cardiovascular disease risk factor lipoprotein(a) (Lp(a)) is elevated in >1.5 billion individuals worldwide, but studies have prioritised European populations. Methods: Here, we examined how ancestrally...
19.
Cullina S, Wojcik G, Shemirani R, Klarin D, Gorman B, Sorokin E, et al.
Front Genet
. 2023 Aug;
14:1181167.
PMID: 37600667
Peripheral artery disease (PAD) is a form of atherosclerotic cardiovascular disease, affecting ∼8 million Americans, and is known to have racial and ethnic disparities. PAD has been reported to have...
20.
Caggiano C, Boudaie A, Shemirani R, Mefford J, Petter E, Chiu A, et al.
Nat Med
. 2023 Jul;
29(7):1845-1856.
PMID: 37464048
An individual's disease risk is affected by the populations that they belong to, due to shared genetics and environmental factors. The study of fine-scale populations in clinical care is important...