Christopher M Schafer
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Explore the profile of Christopher M Schafer including associated specialties, affiliations and a list of published articles.
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13
Citations
100
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Recent Articles
1.
Ma E, Schafer C, Xie J, Rudenko Y, Knapp J, Randi A, et al.
bioRxiv
. 2025 Jan;
PMID: 39763974
Retinopathy of prematurity (ROP) and diabetic retinopathy (DR) are ocular disorders in which a loss of retinal vasculature leads to ischemia followed by a compensatory neovascularization response. In mice, this...
2.
Johnson C, Schafer C, Burge K, Coon B, Chaaban H, Griffin C
bioRxiv
. 2024 Dec;
PMID: 39651150
Graphical Abstract:
3.
Chucair-Elliott A, Pham K, Cleuren A, Schafer C, Griffin C, Ocanas S, et al.
Exp Eye Res
. 2024 Sep;
248():110101.
PMID: 39303842
Endothelial cells (ECs) display organ- and tissue-specific heterogeneity. In the eye, the retinal and choroidal vascular beds are distinct networks with different molecular and morphological properties that serve location-specific functions,...
4.
Ma X, Wu W, Hara M, Zhou J, Panzarin C, Schafer C, et al.
Commun Biol
. 2024 Sep;
7(1):1075.
PMID: 39223298
Subretinal fibrosis permanently impairs the vision of patients with neovascular age-related macular degeneration. Despite emerging evidence revealing the association between disturbed metabolism in retinal pigment epithelium (RPE) and subretinal fibrosis,...
5.
Schafer C, Martin-Almedina S, Kurylowicz K, Dufton N, Osuna-Almagro L, Wu M, et al.
Arterioscler Thromb Vasc Biol
. 2023 Jun;
43(8):1412-1428.
PMID: 37317853
Background: During infectious diseases, proinflammatory cytokines transiently destabilize interactions between adjacent vascular endothelial cells (ECs) to facilitate the passage of immune molecules and cells into tissues. However, in the lung,...
6.
Schafer C, Martin-Almedina S, Kurylowicz K, Dufton N, Osuna-Almagro L, Wu M, et al.
bioRxiv
. 2023 Feb;
PMID: 36798267
Background: During infectious diseases, pro-inflammatory cytokines transiently destabilize interactions between adjacent vascular endothelial cells (ECs) to facilitate the passage of immune molecules and cells into tissues. However, in the lung...
7.
Boland A, Gas-Pascual E, Nottingham B, van der Wel H, Daniel N, Sheikh M, et al.
J Biol Chem
. 2022 Aug;
298(9):102305.
PMID: 35933019
E3-SCF (Skp1/cullin-1/F-box protein) polyubiquitin ligases activate the proteasomal degradation of over a thousand proteins, but the evolutionary diversification of the F-box protein (FBP) family of substrate receptor subunits has challenged...
8.
Schafer C, Gurley J, Kurylowicz K, Lin P, Chen W, Elliott M, et al.
Proc Natl Acad Sci U S A
. 2020 Oct;
117(42):26494-26502.
PMID: 33020273
During the progression of ocular diseases such as retinopathy of prematurity and diabetic retinopathy, overgrowth of retinal blood vessels results in the formation of pathological neovascular tufts that impair vision....
9.
Sheikh M, Thieker D, Chalmers G, Schafer C, Ishihara M, Azadi P, et al.
J Biol Chem
. 2017 Sep;
292(46):18897-18915.
PMID: 28928219
Skp1 is a conserved protein linking cullin-1 to F-box proteins in SCF (kp1/ullin-1/-box protein) E3 ubiquitin ligases, which modify protein substrates with polyubiquitin chains that typically target them for 26S...
10.
Sheikh M, Halmo S, Patel S, Middleton D, Takeuchi H, Schafer C, et al.
Glycobiology
. 2017 Feb;
27(3):206-212.
PMID: 28177478
Determining the correct enzymatic activity of putative glycosyltransferases (GTs) can be challenging as these enzymes can utilize multiple donor and acceptor substrates. Upon initial determination of the donor-sugar nucleotide(s), a...