Christopher M Glinkerman
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Explore the profile of Christopher M Glinkerman including associated specialties, affiliations and a list of published articles.
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17
Citations
223
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Recent Articles
1.
Torrens-Spence M, Matos J, Li T, Kastner D, Kim C, Wang Z, et al.
Nat Commun
. 2024 Nov;
15(1):10356.
PMID: 39609394
Salicylic acid (SA) production in Brassicaceae plants is uniquely accelerated from isochorismate by EPS1, a newly identified enzyme in the BAHD acyltransferase family. We present crystal structures of EPS1 from...
2.
Kim C, Mitchell A, Kastner D, Albright C, Gutierrez M, Glinkerman C, et al.
Nat Commun
. 2023 Feb;
14(1):597.
PMID: 36737607
Plants contain rapidly evolving specialized enzymes that support the biosynthesis of functionally diverse natural products. In coumarin biosynthesis, a BAHD acyltransferase-family enzyme COSY was recently discovered to accelerate coumarin formation...
3.
Glinkerman C, Lin S, Ni J, Li F, Zhao X, Weng J
Commun Chem
. 2023 Jan;
5(1):110.
PMID: 36697794
Sporopollenin is a mechanically robust and chemically inert biopolymer that constitutes the outer protective exine layer of plant spores and pollen grains. Recent investigation of the molecular structure of pine...
4.
Torrens-Spence M, Glinkerman C, Gunther J, Weng J
Curr Opin Plant Biol
. 2021 Jan;
60:101999.
PMID: 33450608
Imine chemistry represents an important category of chemical reactions involved in the biosynthesis of plant natural products, ranging from the newly discovered mobile defense hormone N-hydroxy-pipecolic acid to the red-to-yellow...
5.
Zhu Z, Glinkerman C, Boger D
J Am Chem Soc
. 2020 Nov;
142(49):20778-20787.
PMID: 33252223
An unprecedented 1,4-cycloaddition (vs 3,6-cycloaddition) of 1,2,4,5-tetrazines is described with preformed or in situ generated aryl-conjugated enamines promoted by the solvent hydrogen bonding of hexafluoroisopropanol (HFIP) that is conducted under...
6.
Kim C, Mitchell A, Glinkerman C, Li F, Pluskal T, Weng J
Nat Commun
. 2020 Apr;
11(1):1867.
PMID: 32313070
Plant halogenated natural products are rare and harbor various interesting bioactivities, yet the biochemical basis for the involved halogenation chemistry is unknown. While a handful of Fe(II)- and 2-oxoglutarate-dependent halogenases...
7.
Angelbello A, DeFeo M, Glinkerman C, Boger D, Disney M
ACS Chem Biol
. 2020 Mar;
15(4):849-855.
PMID: 32186845
RNA repeat expansions cause more than 30 neurological and neuromuscular diseases with no known cures. Since repeat expansions operate via diverse pathomechanisms, one potential therapeutic strategy is to rid them...
8.
Torrens-Spence M, Bobokalonova A, Carballo V, Glinkerman C, Pluskal T, Shen A, et al.
Mol Plant
. 2019 Nov;
12(12):1577-1586.
PMID: 31760159
Salicylic acid (SA) is an important phytohormone mediating both local and systemic defense responses in plants. Despite over half a century of research, how plants biosynthesize SA remains unresolved. In...
9.
Ozog S, Timberlake N, Hermann K, Garijo O, Haworth K, Shi G, et al.
Blood
. 2019 Aug;
134(16):1298-1311.
PMID: 31416800
Therapeutic gene delivery to hematopoietic stem cells (HSCs) holds great potential as a life-saving treatment of monogenic, oncologic, and infectious diseases. However, clinical gene therapy is severely limited by intrinsic...
10.
Glinkerman C, Boger D
Org Lett
. 2018 Apr;
20(9):2628-2631.
PMID: 29659291
The synthesis, characterization, and a study of the cycloaddition reactions of 5-nitro-1,2,3-triazine (3) are reported. The electron-deficient nature of 3 permits rapid cycloaddition with a variety of electron-rich dienophiles, including...