Christopher L Keown
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Explore the profile of Christopher L Keown including associated specialties, affiliations and a list of published articles.
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13
Citations
1034
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Recent Articles
1.
Zhang T, Keown C, Wen X, Li J, Vousden D, Anacker C, et al.
Nat Commun
. 2018 Jan;
9(1):298.
PMID: 29352183
Early life experience influences stress reactivity and mental health through effects on cognitive-emotional functions that are, in part, linked to gene expression in the dorsal and ventral hippocampus. The hippocampal...
2.
Abbott A, Linke A, Nair A, Jahedi A, Alba L, Keown C, et al.
Soc Cogn Affect Neurosci
. 2017 Nov;
13(1):32-42.
PMID: 29177509
The neural underpinnings of repetitive behaviors (RBs) in autism spectrum disorders (ASDs), ranging from cognitive to motor characteristics, remain unknown. We assessed RB symptomatology in 50 ASD and 52 typically...
3.
Keown C, Datko M, Chen C, Maximo J, Jahedi A, Muller R
Biol Psychiatry Cogn Neurosci Neuroimaging
. 2017 Sep;
2(1):66-75.
PMID: 28944305
Background: Despite abundant evidence of brain network anomalies in autism spectrum disorder (ASD), findings have varied from broad functional underconnectivity to broad overconnectivity. Rather than pursuing overly simplifying general hypotheses...
4.
Luo C, Keown C, Kurihara L, Zhou J, He Y, Li J, et al.
Science
. 2017 Aug;
357(6351):600-604.
PMID: 28798132
The mammalian brain contains diverse neuronal types, yet we lack single-cell epigenomic assays that are able to identify and characterize them. DNA methylation is a stable epigenetic mark that distinguishes...
5.
Keown C, Berletch J, Castanon R, Nery J, Disteche C, Ecker J, et al.
Proc Natl Acad Sci U S A
. 2017 Mar;
114(14):E2882-E2890.
PMID: 28320934
DNA methylation at gene promoters in a CG context is associated with transcriptional repression, including at genes silenced on the inactive X chromosome in females. Non-CG methylation (mCH) is a...
6.
Shen M, Li D, Keown C, Lee A, Johnson R, Angkustsiri K, et al.
J Am Acad Child Adolesc Psychiatry
. 2016 Aug;
55(9):817-24.
PMID: 27566123
Objective: The objective of this study was to determine whether functional connectivity of the amygdala is altered in preschool-age children with autism spectrum disorder (ASD) and to assess the clinical...
7.
Abbott A, Nair A, Keown C, Datko M, Jahedi A, Fishman I, et al.
Cereb Cortex
. 2015 Sep;
26(10):4034-45.
PMID: 26351318
Autism spectrum disorder (ASD) is characterized by atypical brain network organization, but findings have been inconsistent. While methodological and maturational factors have been considered, the network specificity of connectivity abnormalities...
8.
Chen C, Keown C, Jahedi A, Nair A, Pflieger M, Bailey B, et al.
Neuroimage Clin
. 2015 Jun;
8:238-45.
PMID: 26106547
Despite consensus on the neurological nature of autism spectrum disorders (ASD), brain biomarkers remain unknown and diagnosis continues to be based on behavioral criteria. Growing evidence suggests that brain abnormalities...
9.
Khan A, Nair A, Keown C, Datko M, Lincoln A, Muller R
Biol Psychiatry
. 2015 May;
78(9):625-34.
PMID: 25959247
Background: The cerebellum plays important roles in sensori-motor and supramodal cognitive functions. Cellular, volumetric, and functional abnormalities of the cerebellum have been found in autism spectrum disorders (ASD), but no...
10.
Fishman I, Keown C, Lincoln A, Pineda J, Muller R
JAMA Psychiatry
. 2014 Apr;
71(7):751-60.
PMID: 24740586
Importance: Converging evidence indicates that brain abnormalities in autism spectrum disorder (ASD) involve atypical network connectivity, but it is unclear whether altered connectivity is especially prominent in brain networks that...