Rosa Castanon
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Explore the profile of Rosa Castanon including associated specialties, affiliations and a list of published articles.
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22
Citations
2870
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Recent Articles
1.
Chien J, Liu H, Wang B, Luo C, Bartlett A, Castanon R, et al.
Neuron
. 2024 Jun;
112(15):2524-2539.e5.
PMID: 38838671
Altered transcriptional and epigenetic regulation of brain cell types may contribute to cognitive changes with advanced age. Using single-nucleus multi-omic DNA methylation and transcriptome sequencing (snmCT-seq) in frontal cortex from...
2.
Wang W, Hariharan M, Ding W, Bartlett A, Barragan C, Castanon R, et al.
bioRxiv
. 2023 Jul;
PMID: 37425926
The epigenomic landscape of human immune cells is dynamically shaped by both genetic factors and environmental exposures. However, the relative contributions of these elements are still not fully understood. In...
3.
Wanamaker S, Garza R, MacWilliams A, Nery J, Bartlett A, Castanon R, et al.
Nat Methods
. 2023 Jan;
20(3):469.
PMID: 36690743
No abstract available.
4.
Luo C, Liu H, Xie F, Armand E, Siletti K, Bakken T, et al.
Cell Genom
. 2022 Apr;
2(3).
PMID: 35419551
Single-cell technologies measure unique cellular signatures but are typically limited to a single modality. Computational approaches allow the fusion of diverse single-cell data types, but their efficacy is difficult to...
5.
Gao C, Liu J, Kriebel A, Preissl S, Luo C, Castanon R, et al.
Nat Biotechnol
. 2021 Apr;
39(8):1000-1007.
PMID: 33875866
Integrating large single-cell gene expression, chromatin accessibility and DNA methylation datasets requires general and scalable computational approaches. Here we describe online integrative non-negative matrix factorization (iNMF), an algorithm for integrating...
6.
Lavery L, Ure K, Wan Y, Luo C, Trostle A, Wang W, et al.
Elife
. 2020 Mar;
9.
PMID: 32159514
Methylated cytosine is an effector of epigenetic gene regulation. In the brain, Dnmt3a is the sole 'writer' of atypical non-CpG methylation (mCH), and MeCP2 is the only known 'reader' for...
7.
Zander M, Willige B, He Y, Nguyen T, Langford A, Nehring R, et al.
Elife
. 2019 Aug;
8.
PMID: 31418686
The central regulator of the ethylene (ET) signaling pathway, which controls a plethora of developmental programs and responses to environmental cues in plants, is ETHYLENE-INSENSITIVE2 (EIN2). Here we identify a...
8.
Jupe F, Rivkin A, Michael T, Zander M, Motley S, Sandoval J, et al.
PLoS Genet
. 2019 Jan;
15(1):e1007819.
PMID: 30657772
The bacterium Agrobacterium tumefaciens has been the workhorse in plant genome engineering. Customized replacement of native tumor-inducing (Ti) plasmid elements enabled insertion of a sequence of interest called Transfer-DNA (T-DNA)...
9.
Luo C, Lee Q, Wapinski O, Castanon R, Nery J, Mall M, et al.
Elife
. 2019 Jan;
8.
PMID: 30644360
Direct reprogramming of fibroblasts to neurons induces widespread cellular and transcriptional reconfiguration. Here, we characterized global epigenomic changes during the direct reprogramming of mouse fibroblasts to neurons using whole-genome base-resolution...
10.
Hrit J, Goodrich L, Li C, Wang B, Nie J, Cui X, et al.
Elife
. 2018 Oct;
7.
PMID: 30325306
TET enzymes convert 5-methylcytosine to 5-hydroxymethylcytosine and higher oxidized derivatives. TETs stably associate with and are post-translationally modified by the nutrient-sensing enzyme OGT, suggesting a connection between metabolism and the...