Patterns of Atypical Functional Connectivity and Behavioral Links in Autism Differ Between Default, Salience, and Executive Networks

Overview

Journal Cereb Cortex

Publisher Oxford University Press

Specialty Neurology

Date 2015 Sep 10

PMID 26351318

Citations 93

Authors

Angela E Abbott

Aarti Nair

Christopher L Keown

Michael Datko

Afrooz Jahedi

Inna Fishman

Ralph-Axel Muller

Affiliations

Soon will be listed here.

Abstract

Autism spectrum disorder (ASD) is characterized by atypical brain network organization, but findings have been inconsistent. While methodological and maturational factors have been considered, the network specificity of connectivity abnormalities remains incompletely understood. We investigated intrinsic functional connectivity (iFC) for four "core" functional networks-default-mode (DMN), salience (SN), and left (lECN) and right executive control (rECN). Resting-state functional MRI data from 75 children and adolescents (37 ASD, 38 typically developing [TD]) were included. Functional connectivity within and between networks was analyzed for regions of interest (ROIs) and whole brain, compared between groups, and correlated with behavioral scores. ROI analyses showed overconnectivity (ASD > TD), especially between DMN and ECN. Whole-brain results were mixed. While predominant overconnectivity was found for DMN (posterior cingulate seed) and rECN (right inferior parietal seed), predominant underconnectivity was found for SN (right anterior insula seed) and lECN (left inferior parietal seed). In the ASD group, reduced SN integrity was associated with sensory and sociocommunicative symptoms. In conclusion, atypical connectivity in ASD is network-specific, ranging from extensive overconnectivity (DMN, rECN) to extensive underconnectivity (SN, lECN). Links between iFC and behavior differed between groups. Core symptomatology in the ASD group was predominantly related to connectivity within the salience network.

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References

Anderson J, Nielsen J, Froehlich A, DuBray M, Druzgal T, Cariello A . Functional connectivity magnetic resonance imaging classification of autism. Brain. 2011; 134(Pt 12):3742-54. PMC: 3235557. DOI: 10.1093/brain/awr263. View

Simmons W, Reddish M, Bellgowan P, Martin A . The selectivity and functional connectivity of the anterior temporal lobes. Cereb Cortex. 2009; 20(4):813-25. PMC: 2837089. DOI: 10.1093/cercor/bhp149. View

Weng S, Wiggins J, Peltier S, Carrasco M, Risi S, Lord C . Alterations of resting state functional connectivity in the default network in adolescents with autism spectrum disorders. Brain Res. 2009; 1313:202-14. PMC: 2818723. DOI: 10.1016/j.brainres.2009.11.057. View

Bos D, van Raalten T, Oranje B, Smits A, Kobussen N, Van Belle J . Developmental differences in higher-order resting-state networks in Autism Spectrum Disorder. Neuroimage Clin. 2014; 4:820-7. PMC: 4055902. DOI: 10.1016/j.nicl.2014.05.007. View

Rudie J, Shehzad Z, Hernandez L, Colich N, Bookheimer S, Iacoboni M . Reduced functional integration and segregation of distributed neural systems underlying social and emotional information processing in autism spectrum disorders. Cereb Cortex. 2011; 22(5):1025-37. PMC: 3328339. DOI: 10.1093/cercor/bhr171. View

Shih P, Keehn B, Oram J, Leyden K, Keown C, Muller R . Functional differentiation of posterior superior temporal sulcus in autism: a functional connectivity magnetic resonance imaging study. Biol Psychiatry. 2011; 70(3):270-7. PMC: 3335267. DOI: 10.1016/j.biopsych.2011.03.040. View

Solomon M, Yoon J, Ragland J, Niendam T, Lesh T, Fairbrother W . The development of the neural substrates of cognitive control in adolescents with autism spectrum disorders. Biol Psychiatry. 2013; 76(5):412-21. PMC: 3999330. DOI: 10.1016/j.biopsych.2013.08.036. View

Prado J, Weissman D . Heightened interactions between a key default-mode region and a key task-positive region are linked to suboptimal current performance but to enhanced future performance. Neuroimage. 2011; 56(4):2276-82. DOI: 10.1016/j.neuroimage.2011.03.048. View

Ebisch S, Gallese V, Willems R, Mantini D, Groen W, Luca Romani G . Altered intrinsic functional connectivity of anterior and posterior insula regions in high-functioning participants with autism spectrum disorder. Hum Brain Mapp. 2010; 32(7):1013-28. PMC: 6870194. DOI: 10.1002/hbm.21085. View

10.

Vissers M, Cohen M, Geurts H . Brain connectivity and high functioning autism: a promising path of research that needs refined models, methodological convergence, and stronger behavioral links. Neurosci Biobehav Rev. 2011; 36(1):604-25. DOI: 10.1016/j.neubiorev.2011.09.003. View

11.

Wass S . Distortions and disconnections: disrupted brain connectivity in autism. Brain Cogn. 2010; 75(1):18-28. DOI: 10.1016/j.bandc.2010.10.005. View

12.

Cordes D, Haughton V, Arfanakis K, Carew J, Turski P, Moritz C . Frequencies contributing to functional connectivity in the cerebral cortex in "resting-state" data. AJNR Am J Neuroradiol. 2001; 22(7):1326-33. PMC: 7975218. View

13.

Anticevic A, Repovs G, Shulman G, Barch D . When less is more: TPJ and default network deactivation during encoding predicts working memory performance. Neuroimage. 2009; 49(3):2638-48. PMC: 3226712. DOI: 10.1016/j.neuroimage.2009.11.008. View

14.

Dosenbach N, Fair D, Miezin F, Cohen A, Wenger K, Dosenbach R . Distinct brain networks for adaptive and stable task control in humans. Proc Natl Acad Sci U S A. 2007; 104(26):11073-8. PMC: 1904171. DOI: 10.1073/pnas.0704320104. View

15.

Allen G, Courchesne E . Attention function and dysfunction in autism. Front Biosci. 2001; 6:D105-19. DOI: 10.2741/allen. View

16.

Murphy K, Birn R, Handwerker D, Jones T, Bandettini P . The impact of global signal regression on resting state correlations: are anti-correlated networks introduced?. Neuroimage. 2008; 44(3):893-905. PMC: 2750906. DOI: 10.1016/j.neuroimage.2008.09.036. View

17.

Kana R, Liu Y, Williams D, Keller T, Schipul S, Minshew N . The local, global, and neural aspects of visuospatial processing in autism spectrum disorders. Neuropsychologia. 2013; 51(14):2995-3003. PMC: 3900283. DOI: 10.1016/j.neuropsychologia.2013.10.013. View

18.

Damoiseaux J, Greicius M . Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivity. Brain Struct Funct. 2009; 213(6):525-33. DOI: 10.1007/s00429-009-0208-6. View

19.

Castelli F, Frith C, Happe F, Frith U . Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes. Brain. 2002; 125(Pt 8):1839-49. DOI: 10.1093/brain/awf189. View

20.

Newman S, Carpenter P, Varma S, Just M . Frontal and parietal participation in problem solving in the Tower of London: fMRI and computational modeling of planning and high-level perception. Neuropsychologia. 2003; 41(12):1668-82. DOI: 10.1016/s0028-3932(03)00091-5. View