Christopher K Mathews
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Explore the profile of Christopher K Mathews including associated specialties, affiliations and a list of published articles.
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41
Citations
1450
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Recent Articles
1.
Mathews C
J Biol Chem
. 2019 Nov;
294(44):15898-15899.
PMID: 31676554
Ribonucleotide reductase (RNR) catalyzes the first committed reaction in DNA synthesis. Most of what we know about RNR regulation comes from studies with cultured cells and with purified proteins. In...
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Mathews C
Structure
. 2016 Jun;
24(6):843-4.
PMID: 27276424
Ribonucleotide reductases of the class I family are α2β2 tetramers. Like all RNRs they are subject to allosteric control mechanisms affecting activity and specificity. In this issue of Structure, Johansson...
5.
Mathews C
Nat Rev Cancer
. 2015 Aug;
15(9):528-39.
PMID: 26299592
Cancer was recognized as a genetic disease at least four decades ago, with the realization that the spontaneous mutation rate must increase early in tumorigenesis to account for the many...
6.
Mathews C
FASEB J
. 2014 Jun;
28(9):3832-40.
PMID: 24928192
For >35 yr, we have known that the accuracy of DNA replication is controlled in large part by the relative concentrations of the 4 canonical deoxyribonucleoside 5'-triphosphates (dNTPs) at the...
7.
Chimploy K, Song S, Wheeler L, Mathews C
J Biol Chem
. 2013 Mar;
288(18):13145-55.
PMID: 23504325
Deoxyribonucleoside triphosphate pools in mammalian mitochondria are highly asymmetric, and this asymmetry probably contributes to the elevated mutation rate for the mitochondrial genome as compared with the nuclear genome. To...
8.
Mannava S, Moparthy K, Wheeler L, Leonova K, Wawrzyniak J, Bianchi-Smiraglia A, et al.
Aging (Albany NY)
. 2012 Dec;
4(12):917-22.
PMID: 23249808
The down-regulation of dominant oncogenes, including C-MYC, in tumor cells often leads to the induction of senescence via mechanisms that are not completely identified. In the current study, we demonstrate...
9.
Mannava S, Moparthy K, Wheeler L, Natarajan V, Zucker S, Fink E, et al.
Am J Pathol
. 2012 Dec;
182(1):142-51.
PMID: 23245831
In normal human cells, oncogene-induced senescence (OIS) depends on induction of DNA damage response. Oxidative stress and hyperreplication of genomic DNA have been proposed as major causes of DNA damage...
10.
Schaaper R, Mathews C
DNA Repair (Amst)
. 2012 Dec;
12(1):73-9.
PMID: 23218950
The accuracy of DNA synthesis depends on the accuracy of the polymerase as well as the quality and concentration(s) of the available 5'-deoxynucleoside-triphosphate DNA precursors (dNTPs). The relationships between dNTPs...