Christopher J Trabbic
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Explore the profile of Christopher J Trabbic including associated specialties, affiliations and a list of published articles.
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11
Citations
247
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Recent Articles
1.
Oppong F, Li Z, Akbari Fakhrabadi E, Raorane T, Giri P, Liberatore M, et al.
J Pharm Sci
. 2020 May;
109(9):2719-2728.
PMID: 32473210
A new indole based chalcone molecule MOMIPP induced methuosis mediated cell death in gliobastoma and other cancer cell lines. But the drug was insoluble in water and had a very...
2.
Li Z, Mbah N, Overmeyer J, Sarver J, George S, Trabbic C, et al.
BMC Cancer
. 2019 Jan;
19(1):77.
PMID: 30651087
Background: Synthetic indolyl- pyridinyl- propenones (IPPs) induce methuosis, a form of non-apoptotic cell death, in glioblastoma and other cancer cell lines. Methuosis is characterized by accumulation of cytoplasmic vacuoles derived...
3.
Du S, Sarver J, Trabbic C, Erhardt P, Schroering A, Maltese W
Cancer Chemother Pharmacol
. 2018 Nov;
83(2):237-254.
PMID: 30426158
Purpose: 3-(6-Methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propene-1-one (6-MOMIPP) is a novel indole-based chalcone that disrupts microtubules. The present study aims to define the mechanism through which 6-MOMIPP induces cell death and to evaluate the efficacy...
4.
Heyza J, Arora S, Zhang H, Conner K, Lei W, Floyd A, et al.
Nutrients
. 2018 Nov;
10(11).
PMID: 30400270
The 5'-3' structure-specific endonuclease ERCC1/XPF (Excision Repair Cross-Complementation Group 1/Xeroderma Pigmentosum group F) plays critical roles in the repair of cisplatin-induced DNA damage. As such, it has been identified as...
5.
Trabbic C, George S, Alexander E, Du S, Offenbacher J, Crissman E, et al.
Eur J Med Chem
. 2016 Jun;
122:79-91.
PMID: 27343855
Certain indolyl-pyridinyl-propenone analogues kill glioblastoma cells that have become resistant to conventional therapeutic drugs. Some of these analogues induce a novel form of non-apoptotic cell death called methuosis, while others...
6.
Hinds Jr T, John K, McBeth L, Trabbic C, Sanchez E
PPAR Res
. 2016 May;
2016:6218637.
PMID: 27190501
Nutrient overload and genetic factors have led to a worldwide epidemic of obesity that is the underlying cause of diabetes, atherosclerosis, and cardiovascular disease. In this study, we used macrolide...
7.
Stec D, John K, Trabbic C, Luniwal A, Hankins M, Baum J, et al.
PLoS One
. 2016 Apr;
11(4):e0153427.
PMID: 27071062
Numerous clinical and population studies have demonstrated that increased serum bilirubin levels protect against cardiovascular and metabolic diseases such as obesity and diabetes. Bilirubin is a potent antioxidant, and the...
8.
Trabbic C, Zhang F, Walseth T, Slama J
J Med Chem
. 2015 Apr;
58(8):3593-610.
PMID: 25826221
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a Ca(2+) releasing intracellular second messenger in both mammals and echinoderms. We report that large functionalized substituents introduced at the nicotinic acid 5-position...
9.
Trabbic C, Overmeyer J, Alexander E, Crissman E, Kvale H, Smith M, et al.
J Med Chem
. 2015 Feb;
58(5):2489-512.
PMID: 25654321
Methuosis is a form of nonapoptotic cell death characterized by an accumulation of macropinosome-derived vacuoles with eventual loss of membrane integrity. Small molecules inducing methuosis could offer significant advantages compared...
10.
Trabbic C, Dietsch H, Alexander E, Nagy P, Robinson M, Overmeyer J, et al.
ACS Med Chem Lett
. 2014 Feb;
5(1):73-77.
PMID: 24527179
Because many cancers harbor mutations that confer resistance to apoptosis, there is a need for therapeutic agents that can trigger alternative forms of cell death. Methuosis is a novel form...