Christopher J Shoemaker
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Explore the profile of Christopher J Shoemaker including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
North B, Ohnstad A, Ragusa M, Shoemaker C
J Cell Biol
. 2025 Feb;
224(4).
PMID: 39928048
During autophagy, toxic cargo is encapsulated by autophagosomes and trafficked to lysosomes for degradation. NBR1, an autophagy receptor targeting ubiquitinated aggregates, serves as a model for studying the multivalent, heterotypic...
2.
North B, Ohnstad A, Ragusa M, Shoemaker C
bioRxiv
. 2024 May;
PMID: 38766171
During autophagy, potentially toxic cargo is enveloped by a newly formed autophagosome and trafficked to the lysosome for degradation. Ubiquitinated protein aggregates, a key target for autophagy, are identified by...
3.
Delgado J, Shoemaker C
Autophagy
. 2024 Mar;
20(6):1447-1448.
PMID: 38449384
Mitophagy is a cellular process that enables the selective degradation of damaged, dysfunctional, or superfluous mitochondria. During mitophagy, specific proteins recognize and tag mitochondria for degradation. These tagged mitochondria are...
4.
Phelan J, Scheich S, Choi J, Wright G, Haupl B, Young R, et al.
Cancer Cell
. 2024 Jan;
42(2):238-252.e9.
PMID: 38215749
Diffuse large B cell lymphoma (DLBCL) is an aggressive, profoundly heterogeneous cancer, presenting a challenge for precision medicine. Bruton's tyrosine kinase (BTK) inhibitors block B cell receptor (BCR) signaling and...
5.
Delgado J, Shepard L, Lamson S, Liu S, Shoemaker C
EMBO J
. 2024 Jan;
43(1):32-60.
PMID: 38177312
Lysosomal degradation of autophagy receptors is a common proxy for selective autophagy. However, we find that two established mitophagy receptors, BNIP3 and BNIP3L/NIX, are constitutively delivered to lysosomes in an...
6.
Delgado J, Shepard L, Lamson S, Liu S, Shoemaker C
bioRxiv
. 2023 Mar;
PMID: 36993512
Lysosomal degradation of autophagy receptors is a common proxy for selective autophagy. However, we find that two established mitophagy receptors, BNIP3 and BNIP3L/NIX, violate this assumption. Rather, BNIP3 and NIX...
7.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
8.
Ohnstad A, Delgado J, North B, Nasa I, Kettenbach A, Schultz S, et al.
EMBO J
. 2020 Nov;
39(24):e104948.
PMID: 33226137
Autophagosome formation requires multiple autophagy-related (ATG) factors. However, we find that a subset of autophagy substrates remains robustly targeted to the lysosome in the absence of several core ATGs, including...
9.
An H, Ordureau A, Paulo J, Shoemaker C, Denic V, Harper J
Mol Cell
. 2019 Apr;
74(5):891-908.e10.
PMID: 31006537
Cells respond to nutrient stress by trafficking cytosolic contents to lysosomes for degradation via macroautophagy. The endoplasmic reticulum (ER) serves as an initiation site for autophagosomes and is also remodeled...
10.
Shoemaker C, Huang T, Weir N, Polyakov N, Schultz S, Denic V
PLoS Biol
. 2019 Apr;
17(4):e2007044.
PMID: 30933966
The power of forward genetics in yeast is the foundation on which the field of autophagy research firmly stands. Complementary work on autophagy in higher eukaryotes has revealed both the...