Christopher J Petell
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Explore the profile of Christopher J Petell including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
210
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0
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Recent Articles
1.
Petell C, Burkholder N, Ruiz P, Skela J, Foreman J, Southwell L, et al.
J Biol Chem
. 2023 Jul;
299(8):104996.
PMID: 37394010
A critical component of gene regulation is recognition of histones and their post-translational modifications by transcription-associated proteins or complexes. Although many histone-binding reader modules have been characterized, the bromo-adjacent homology...
2.
Mensah I, Norvil A, AlAbdi L, McGovern S, Petell C, He M, et al.
NAR Cancer
. 2021 Dec;
3(4):zcab045.
PMID: 34870206
In mammals, DNA methyltransferases DNMT1 and DNMT3's (A, B and L) deposit and maintain DNA methylation in dividing and nondividing cells. Although these enzymes have an unremarkable DNA sequence specificity...
3.
Petell C, Randene K, Pappas M, Sandoval D, Strahl B, Harrison J, et al.
Elife
. 2021 Sep;
10.
PMID: 34581668
Measuring protein-protein interaction (PPI) affinities is fundamental to biochemistry. Yet, conventional methods rely upon the law of mass action and cannot measure many PPIs due to a scarcity of reagents...
4.
Tencer A, Cox K, Wright G, Zhang Y, Petell C, Klein B, et al.
Nat Commun
. 2020 Oct;
11(1):5466.
PMID: 33122719
Human Microrchidia 4 (MORC4) is associated with acute and chronic pancreatitis, inflammatory disorders and cancer but it remains largely uncharacterized. Here, we describe the structure-function relationship of MORC4 and define...
5.
Ren W, Fan H, Grimm S, Guo Y, Kim J, Yin J, et al.
Proc Natl Acad Sci U S A
. 2020 Jul;
117(31):18439-18447.
PMID: 32675241
In mammals, repressive histone modifications such as trimethylation of histone H3 Lys9 (H3K9me3), frequently coexist with DNA methylation, producing a more stable and silenced chromatin state. However, it remains elusive...
6.
Albanese K, Krone M, Petell C, Parker M, Strahl B, Brustad E, et al.
ACS Chem Biol
. 2019 Oct;
15(1):103-111.
PMID: 31634430
Histone post-translational modifications (PTMs) are crucial for many cellular processes including mitosis, transcription, and DNA repair. The cellular readout of histone PTMs is dependent on both the chemical modification and...
7.
Petell C, Pham A, Skela J, Strahl B
Sci Rep
. 2019 Apr;
9(1):6265.
PMID: 31000785
Histone post-translational modifications contribute to chromatin function largely through the recruitment of effector proteins that contain specialized "reader" domains. While a significant number of reader domains have been characterized for...
8.
Petell C, Loiseau G, Gandy R, Pradhan S, Gowher H
Anal Biochem
. 2017 Jun;
533:1-9.
PMID: 28624296
DNA methylation is a highly conserved epigenetic modification with critical roles ranging from protection against phage infection in bacteria to the regulation of gene expression in mammals. DNA methylation at...
9.
Norvil A, Petell C, AlAbdi L, Wu L, Rossie S, Gowher H
Biochemistry
. 2016 Oct;
57(29):4312-4324.
PMID: 27768276
The catalytic domains of the de novo DNA methyltransferases Dnmt3a-C and Dnmt3b-C are highly homologous. However, their unique biochemical properties could potentially contribute to differences in the substrate preferences or...
10.
Petell C, AlAbdi L, He M, San Miguel P, Rose R, Gowher H
Nucleic Acids Res
. 2016 May;
44(16):7605-17.
PMID: 27179026
Coordinated regulation of gene expression that involves activation of lineage specific genes and repression of pluripotency genes drives differentiation of embryonic stem cells (ESC). For complete repression of pluripotency genes...