Christopher J Pelham
Overview
Explore the profile of Christopher J Pelham including associated specialties, affiliations and a list of published articles.
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21
Citations
593
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Recent Articles
1.
Madan E, Palma A, Vudatha V, Kumar A, Bhoopathi P, Wilhelm J, et al.
Nat Biotechnol
. 2024 Dec;
PMID: 39653752
Cell competition and fitness comparison between cancer and tumor microenvironment (TME) cells determine oncogenic fate. Our previous study established a role for human Flower isoforms as fitness fingerprints, where the...
2.
Yekelchyk M, Madan E, Wilhelm J, Short K, Palma A, Liao L, et al.
EMBO Mol Med
. 2021 Oct;
13(11):e13714.
PMID: 34661368
Risk stratification of COVID-19 patients is essential for pandemic management. Changes in the cell fitness marker, hFwe-Lose, can precede the host immune response to infection, potentially making such a biomarker...
3.
Camacho D, Jesus J, Palma A, Martins S, Afonso A, Peixoto M, et al.
Adv Cancer Res
. 2020 Jul;
148:171-199.
PMID: 32723563
Cancer is a complex disease with high incidence and mortality rates. The important role played by the tumor microenvironment in regulating oncogenesis, tumor growth, and metastasis is by now well...
4.
Madan E, Parker T, Pelham C, Palma A, Peixoto M, Nagane M, et al.
Nucleic Acids Res
. 2019 Sep;
47(19):10212-10234.
PMID: 31538203
Chronic hypoxia is associated with a variety of physiological conditions such as rheumatoid arthritis, ischemia/reperfusion injury, stroke, diabetic vasculopathy, epilepsy and cancer. At the molecular level, hypoxia manifests its effects...
5.
Madan E, Pelham C, Nagane M, Parker T, Canas-Marques R, Fazio K, et al.
Nature
. 2019 Jul;
572(7768):260-264.
PMID: 31341286
In humans, the adaptive immune system uses the exchange of information between cells to detect and eliminate foreign or damaged cells; however, the removal of unwanted cells does not always...
6.
Pelham C, Nagane M, Madan E
Semin Cancer Biol
. 2019 Jul;
63:11-18.
PMID: 31323289
In many cases, cancers are difficult to eliminate because they develop resistance to a primary chemotherapy or targeted therapy. Tumors grow into diverse cell subpopulations, increasing the ability to resist...
7.
Madan E, Parker T, Bauer M, Dhiman A, Pelham C, Nagane M, et al.
J Biol Chem
. 2018 Feb;
293(12):4262-4276.
PMID: 29382728
p53 is an important tumor-suppressor protein that is mutated in more than 50% of cancers. Strategies for restoring normal p53 function are complicated by the oncogenic properties of mutant p53...
8.
Pelham C, Drews E, Agrawal D
J Mol Cell Cardiol
. 2016 Jul;
98:1-10.
PMID: 27374117
Vitamin D deficiency in human subjects is associated with hypertension, metabolic syndrome and related risk factors of cardiovascular diseases. Serum 25-hydroxyvitamin D levels correlate inversely with adiposity in obese and...
9.
Ikhapoh I, Pelham C, Agrawal D
Stem Cells Int
. 2015 Jun;
2015:498328.
PMID: 26106428
Coronary artery stenting or angioplasty procedures frequently result in long-term endothelial dysfunction or loss and complications including arterial thrombosis and myocardial infarction. Stem cell-based therapies have been proposed to support...
10.
Ikhapoh I, Pelham C, Agrawal D
Differentiation
. 2015 Apr;
89(3-4):87-96.
PMID: 25913202
Objective: Mesenchymal stem cells (MSC) have shown therapeutic potential to engraft and either differentiate into or support differentiation of vascular endothelial cells (EC), smooth muscle cells and cardiomyocytes in animal...