Christopher J Oldfield
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Explore the profile of Christopher J Oldfield including associated specialties, affiliations and a list of published articles.
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72
Citations
8257
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Recent Articles
11.
Oldfield C, Peng Z, Kurgan L
Methods Mol Biol
. 2020 Jan;
2106:225-239.
PMID: 31889261
RNA chaperone activity is one of the many functions of intrinsically disordered regions (IDRs). IDRs function without the prerequisite of a stable structure. Instead, their functions arise from structural ensembles....
12.
Oldfield C, Duhamel T, Dhalla N
Can J Physiol Pharmacol
. 2019 Dec;
98(2):74-84.
PMID: 31815523
The heart is capable of responding to stressful situations by increasing muscle mass, which is broadly defined as cardiac hypertrophy. This phenomenon minimizes ventricular wall stress for the heart undergoing...
13.
Ghadermarzi S, Katuwawala A, Oldfield C, Barik A, Kurgan L
Pac Symp Biocomput
. 2019 Dec;
25:171-182.
PMID: 31797595
Intrinsically disorder regions (IDRs) lack a stable structure, yet perform biological functions. The functions of IDRs include mediating interactions with other molecules, including proteins, DNA, or RNA and entropic functions,...
14.
Alterovitz W, Faraggi E, Oldfield C, Meng J, Xue B, Huang F, et al.
Pac Symp Biocomput
. 2019 Dec;
25:159-170.
PMID: 31797594
Disordered binding regions (DBRs), which are embedded within intrinsically disordered proteins or regions (IDPs or IDRs), enable IDPs or IDRs to mediate multiple protein-protein interactions. DBR-protein complexes were collected from...
15.
Katuwawala A, Oldfield C, Kurgan L
Protein Sci
. 2019 Oct;
29(1):184-200.
PMID: 31642118
The intense interest in the intrinsically disordered proteins in the life science community, together with the remarkable advancements in predictive technologies, have given rise to the development of a large...
16.
Katuwawala A, Oldfield C, Kurgan L
Brief Bioinform
. 2019 Oct;
21(5):1509-1522.
PMID: 31616935
Experimental annotations of intrinsic disorder are available for 0.1% of 147 000 000 of currently sequenced proteins. Over 60 sequence-based disorder predictors were developed to help bridge this gap. Current...
17.
Boreskie K, Hay J, Kehler D, Johnston N, Rose A, Oldfield C, et al.
Clin Geriatr Med
. 2019 Sep;
35(4):571-585.
PMID: 31543187
The wait before elective cardiac intervention or surgery presents an opportunity to prevent further physiologic decline preoperatively in older patients. Implementation of prehabilitation programs decreases length of hospital stay postoperatively,...
18.
Zhou J, Oldfield C, Yan W, Shen B, Dunker A
Protein Sci
. 2019 Jul;
28(9):1652-1663.
PMID: 31299122
Disordered domains are long regions of intrinsic disorder that ideally have conserved sequences, conserved disorder, and conserved functions. These domains were first noticed in protein-protein interactions that are distinct from...
19.
Oldfield C, Peng Z, Uversky V, Kurgan L
Cell Mol Life Sci
. 2019 Jun;
77(1):149-160.
PMID: 31175370
Protein-coding nucleic acids exhibit composition and codon biases between sequences coding for intrinsically disordered regions (IDRs) and those coding for structured regions. IDRs are regions of proteins that are folding...
20.
Oldfield C, Chen K, Kurgan L
Methods Mol Biol
. 2019 Apr;
1958:73-100.
PMID: 30945214
Many new methods for the sequence-based prediction of the secondary and supersecondary structures have been developed over the last several years. These and older sequence-based predictors are widely applied for...