Christopher J Oldfield
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Explore the profile of Christopher J Oldfield including associated specialties, affiliations and a list of published articles.
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72
Citations
8257
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Recent Articles
1.
Oldfield C, Moffatt T, Dolinsky V, Duhamel T
Can J Physiol Pharmacol
. 2021 Oct;
100(4):361-370.
PMID: 34695364
Sarco(endo)plasmic reticulum calcium (Ca) ATPase (SERCA) transports Ca in muscle. Impaired SERCA activity may contribute to diabetic myopathy. Sirtuin (SIRT) 3 regulates muscle metabolism and function; however, it is unknown...
2.
Song R, Cao B, Peng Z, Oldfield C, Kurgan L, Wong K, et al.
Biomolecules
. 2021 Sep;
11(9).
PMID: 34572550
Non-synonymous single nucleotide polymorphisms (nsSNPs) may result in pathogenic changes that are associated with human diseases. Accurate prediction of these deleterious nsSNPs is in high demand. The existing predictors of...
3.
Zhao B, Katuwawala A, Oldfield C, Hu G, Wu Z, Uversky V, et al.
J Mol Biol
. 2021 Sep;
433(21):167229.
PMID: 34487791
Although RNA-binding proteins (RBPs) are known to be enriched in intrinsic disorder, no previous analysis focused on RBPs interacting with specific RNA types. We fill this gap with a comprehensive...
4.
Oldfield C, Moffatt T, OHara K, Xiang B, Dolinsky V, Duhamel T
Physiol Rep
. 2021 Aug;
9(16):e14961.
PMID: 34405591
Obesity, type 2 diabetes, and heart disease are linked to an unhealthy diet. Sarco(endo)plasmic reticulum calcium (Ca ) ATPase 2a (SERCA2a) controls cardiac function by transporting Ca in cardiomyocytes. SERCA2a...
5.
Zhao B, Katuwawala A, Oldfield C, Dunker A, Faraggi E, Gsponer J, et al.
Nucleic Acids Res
. 2020 Oct;
49(D1):D298-D308.
PMID: 33119734
We present DescribePROT, the database of predicted amino acid-level descriptors of structure and function of proteins. DescribePROT delivers a comprehensive collection of 13 complementary descriptors predicted using 10 popular and...
6.
Zhou J, Oldfield C, Yan W, Shen B, Dunker A
ACS Omega
. 2020 Aug;
5(29):17883-17891.
PMID: 32743159
Background: Intrinsically disordered proteins or regions (IDPs or IDRs) lack stable structures in solution, yet often fold upon binding with partners. IDPs or IDRs are highly abundant in all proteomes...
7.
Giri R, Bhardwaj T, Shegane M, Gehi B, Kumar P, Gadhave K, et al.
Cell Mol Life Sci
. 2020 Jul;
78(4):1655-1688.
PMID: 32712910
The recently emerged coronavirus designated as SARS-CoV-2 (also known as 2019 novel coronavirus (2019-nCoV) or Wuhan coronavirus) is a causative agent of coronavirus disease 2019 (COVID-19), which is rapidly spreading...
8.
Oldfield C, Fan X, Wang C, Dunker A, Kurgan L
Methods Mol Biol
. 2020 Jul;
2141:21-35.
PMID: 32696351
Intrinsically disordered proteins are either entirely disordered or contain disordered regions in their native state. These proteins and regions function without the prerequisite of a stable structure and were found...
9.
Wu Z, Hu G, Oldfield C, Kurgan L
Methods Mol Biol
. 2020 Jul;
2165:83-101.
PMID: 32621220
Intrinsically disordered regions (IDRs) are estimated to be highly abundant in nature. While only several thousand proteins are annotated with experimentally derived IDRs, computational methods can be used to predict...
10.
Boreskie K, Oldfield C, Hay J, Moffatt T, Hiebert B, Arora R, et al.
Exp Gerontol
. 2020 Feb;
133:110859.
PMID: 32017952
Frailty is a risk factor for cardiovascular disease (CVD). Biomarkers have the potential to detect the early stages of frailty, such as pre-frailty. Myokines may act as biomarkers of frailty-related...