Christopher J ODonnell
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Explore the profile of Christopher J ODonnell including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Kavousi M, Bos M, Barnes H, Lino Cardenas C, Wong D, Lu H, et al.
Nat Genet
. 2023 Sep;
55(10):1651-1664.
PMID: 37770635
Coronary artery calcification (CAC), a measure of subclinical atherosclerosis, predicts future symptomatic coronary artery disease (CAD). Identifying genetic risk factors for CAC may point to new therapeutic avenues for prevention....
12.
Urbut S, Koyama S, Hornsby W, Bhukar R, Kheterpal S, Truong B, et al.
iScience
. 2023 Sep;
26(10):107854.
PMID: 37766997
While lipid traits are known essential mediators of cardiovascular disease, few approaches have taken advantage of their shared genetic effects. We apply a Bayesian multivariate size estimator, mash, to GWAS...
13.
Zhang X, Brody J, Graff M, Highland H, Chami N, Xu H, et al.
medRxiv
. 2023 Sep;
PMID: 37662265
Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European...
14.
van de Vegte Y, Eppinga R, van der Ende M, Hagemeijer Y, Mahendran Y, Salfati E, et al.
Nat Commun
. 2023 Aug;
14(1):4646.
PMID: 37532724
Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate...
15.
McInturff E, France S, Leverett C, Flick A, Lindsey E, Berritt S, et al.
J Med Chem
. 2023 Aug;
66(15):10150-10201.
PMID: 37528515
Each year, new drugs are introduced to the market, representing structures that have affinity for biological targets implicated in human diseases and conditions. These new chemical entities (NCEs), particularly small...
16.
Verma A, Huffman J, Rodriguez A, Conery M, Liu M, Ho Y, et al.
medRxiv
. 2023 Jul;
PMID: 37425708
Genome-wide association studies (GWAS) have underrepresented individuals from non-European populations, impeding progress in characterizing the genetic architecture and consequences of health and disease traits. To address this, we present a...
17.
Graham S, Clarke S, Wu K, Kanoni S, Zajac G, Ramdas S, et al.
Nature
. 2023 May;
618(7965):E19-E20.
PMID: 37237109
No abstract available.
18.
Barat A, Chen C, Patel-Murray N, McMurray J, Packer M, Solomon S, et al.
Eur J Heart Fail
. 2023 May;
25(8):1256-1266.
PMID: 37191081
Aims: To evaluate the prevalence of pathogenic variants in genes associated with dilated cardiomyopathy (DCM) in a clinical trial population with heart failure and reduced ejection fraction (HFrEF) and describe...
19.
Vassy J, Posner D, Ho Y, Gagnon D, Galloway A, Tanukonda V, et al.
JAMA Cardiol
. 2023 May;
8(6):564-574.
PMID: 37133828
Importance: Primary prevention of atherosclerotic cardiovascular disease (ASCVD) relies on risk stratification. Genome-wide polygenic risk scores (PRSs) are proposed to improve ASCVD risk estimation. Objective: To determine whether genome-wide PRSs...
20.
Chen H, Dina C, Small A, Shaffer C, Levinson R, Helgadottir A, et al.
Eur Heart J
. 2023 Apr;
44(21):1927-1939.
PMID: 37038246
Aims: Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely understood. The aim of this study was to discover novel genetic contributors to AS and to...