Christopher J OBrien
Overview
Explore the profile of Christopher J OBrien including associated specialties, affiliations and a list of published articles.
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80
Citations
1705
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Recent Articles
1.
Shahfar H, OBrien C, Budyak I, Roberts C
Mol Pharm
. 2022 Oct;
19(11):3820-3830.
PMID: 36194430
Static light scattering (SLS) was used to characterize five monoclonal antibodies (MAbs) as a function of total ionic strength (TIS) at pH values between 5.5 and 7.0. Second osmotic virial...
2.
Kirk A, OBrien C, Krenske E
Chem Commun (Camb)
. 2020 Jan;
56(8):1227-1230.
PMID: 31897455
Organophosphine-mediated reactions that generate P[double bond, length as m-dash]O-bonded byproducts can be transformed into catalytic processes by reducing the R3P[double bond, length as m-dash]O byproduct back to PR3in situ with...
3.
Liew Z, Fenton A, Harigopal S, Gopalakaje S, Brodlie M, OBrien C
Arch Dis Child Fetal Neonatal Ed
. 2019 May;
105(1):87-93.
PMID: 31123057
Objective: High-flow nasal cannula (HFNC) therapy is increasingly used in preterm infants despite a paucity of physiological studies. We aimed to investigate the effects of HFNC on respiratory physiology. Study...
4.
Heckman N, Foiles S, OBrien C, Chandross M, Barr C, Argibay N, et al.
Nanoscale
. 2018 Nov;
10(45):21231-21243.
PMID: 30417913
Nanocrystalline metals offer significant improvements in structural performance over conventional alloys. However, their performance is limited by grain boundary instability and limited ductility. Solute segregation has been proposed as a...
5.
Fianchini M, OBrien C, Chass G
J Org Chem
. 2018 May;
84(17):10579-10592.
PMID: 29812942
Important stoichiometric transformations like Wittig and Appel reactions have been implemented in a catalytic fashion in the past decade. The phosphine oxide generated in situ can be reintroduced as phosphine...
6.
OBrien C, Calero-Rubio C, Razinkov V, Robinson A, Roberts C
Protein Sci
. 2018 Apr;
27(7):1275-1285.
PMID: 29637646
Colloidal protein-protein interactions (PPI) are often expected to impact key behaviors of proteins in solution, such as aggregation rates and mechanisms, aggregate structure, protein solubility, and solution viscosity. PPI of...
7.
Preece C, Perry A, Gray B, Kenna D, Jones A, Cummings S, et al.
J Cyst Fibros
. 2015 May;
15(2):186-91.
PMID: 26002312
Background: Isolation of mycobacteria from the sputum of patients with cystic fibrosis (CF) is challenging due to the overgrowth of cultures by other bacteria and fungi. In this setting, Burkholderia...
8.
Coyle E, Doonan B, Holohan A, Walsh K, Lavigne F, Krenske E, et al.
Angew Chem Int Ed Engl
. 2014 Sep;
53(47):12907-11.
PMID: 25250907
The first examples of catalytic Wittig reactions with semistabilized and nonstabilized ylides are reported. These reactions were enabled by utilization of a masked base, sodium tert-butyl carbonate, and/or ylide tuning....
9.
Costanzo J, OBrien C, Tiller K, Tamargo E, Robinson A, Roberts C, et al.
Protein Eng Des Sel
. 2014 Apr;
27(5):157-67.
PMID: 24722670
Non-native protein aggregation is a prevalent problem occurring in many biotechnological manufacturing processes and can compromise the biological activity of the target molecule or induce an undesired immune response. Additionally,...
10.
Haq I, Gopalakaje S, Fenton A, McKean M, OBrien C, Brodlie M
Paediatr Respir Rev
. 2014 Jan;
15(2):124-34.
PMID: 24472697
High flow nasal cannula (HFNC) devices deliver an adjustable mixture of heated and humidified oxygen and air at a variable flow rate. Over recent years HFNC devices have become a...