Christopher J Caunt
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Explore the profile of Christopher J Caunt including associated specialties, affiliations and a list of published articles.
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37
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1408
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Recent Articles
1.
Kidger A, Saville M, Rushworth L, Davidson J, Stellzig J, Ono M, et al.
Oncogene
. 2022 Apr;
41(20):2811-2823.
PMID: 35418690
The cytoplasmic phosphatase DUSP6 and its nuclear counterpart DUSP5 are negative regulators of RAS/ERK signalling. Here we use deletion of either Dusp5 or Dusp6 to explore the roles of these...
2.
Hey F, Andreadi C, Noble C, Patel B, Jin H, Kamata T, et al.
Heliyon
. 2019 Jan;
4(12):e01065.
PMID: 30603699
BRAF is a cytoplasmic protein kinase, which activates the MEK-ERK signalling pathway. Deregulation of the pathway is associated with the presence of mutations in human cancer, the most common being...
3.
Sipthorp J, Lebraud H, Gilley R, Kidger A, Okkenhaug H, Saba-El-Leil M, et al.
Bioconjug Chem
. 2017 Apr;
28(6):1677-1683.
PMID: 28449575
The RAS-RAF-MEK-ERK pathway has been intensively studied in oncology, with RAS known to be mutated in ∼30% of all human cancers. The recent emergence of ERK1/2 inhibitors and their ongoing...
4.
Kidger A, Rushworth L, Stellzig J, Davidson J, Bryant C, Bayley C, et al.
Proc Natl Acad Sci U S A
. 2017 Jan;
114(3):E317-E326.
PMID: 28053233
Deregulated extracellular signal-regulated kinase (ERK) signaling drives cancer growth. Normally, ERK activity is self-limiting by the rapid inactivation of upstream kinases and delayed induction of dual-specificity MAP kinase phosphatases (MKPs/DUSPs)....
5.
Caunt C, Kidger A, Keyse S
Methods Mol Biol
. 2016 Aug;
1447:197-215.
PMID: 27514808
The spatiotemporal regulation of the Ras/ERK pathway is critical in determining the physiological and pathophysiological outcome of signaling. Dual-specificity mitogen-activated protein kinase (MAPK) phosphatases (DUSPs or MKPs) are key regulators...
6.
Naidu S, Sutherland C, Zhang Y, Risco A, de la Vega L, Caunt C, et al.
Mol Cell Biol
. 2016 Jun;
36(18):2403-17.
PMID: 27354066
Heat shock factor 1 (HSF1) monitors the structural integrity of the proteome. Phosphorylation at S326 is a hallmark for HSF1 activation, but the identity of the kinase(s) phosphorylating this site...
7.
Garner K, Perrett R, Voliotis M, Bowsher C, Pope G, Pham T, et al.
J Biol Chem
. 2015 Dec;
291(5):2246-59.
PMID: 26644469
Cell signaling pathways are noisy communication channels, and statistical measures derived from information theory can be used to quantify the information they transfer. Here we use single cell signaling measures...
8.
Caunt C, Sale M, Smith P, Cook S
Nat Rev Cancer
. 2015 Sep;
15(10):577-92.
PMID: 26399658
The role of the ERK signalling pathway in cancer is thought to be most prominent in tumours in which mutations in the receptor tyrosine kinases RAS, BRAF, CRAF, MEK1 or...
9.
Rushworth L, Kidger A, Delavaine L, Stewart G, van Schelven S, Davidson J, et al.
Proc Natl Acad Sci U S A
. 2014 Dec;
111(51):18267-72.
PMID: 25489104
Ectopic expression of dual-specificity phosphatase 5 (DUSP5), an inducible mitogen-activated protein (MAP) kinase phosphatase, specifically inactivates and anchors extracellular signal-regulated kinase (ERK)1/2 in the nucleus. However, the role of endogenous...
10.
Bryant C, Keyse S, Caunt C
Pigment Cell Melanoma Res
. 2014 Jul;
27(5):693-5.
PMID: 24995574
No abstract available.