Christopher J Carbone
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Explore the profile of Christopher J Carbone including associated specialties, affiliations and a list of published articles.
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16
Citations
855
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Recent Articles
1.
Ortiz A, Gui J, Zahedi F, Yu P, Cho C, Bhattacharya S, et al.
Cancer Cell
. 2019 Jan;
35(1):33-45.e6.
PMID: 30645975
Tumor-derived extracellular vesicles (TEV) "educate" healthy cells to promote metastases. We found that melanoma TEV downregulated type I interferon (IFN) receptor and expression of IFN-inducible cholesterol 25-hydroxylase (CH25H). CH25H produces...
2.
Katlinski K, Gui J, Katlinskaya Y, Ortiz A, Chakraborty R, Bhattacharya S, et al.
Cancer Cell
. 2017 Feb;
31(2):194-207.
PMID: 28196594
Refractoriness of solid tumors, including colorectal cancers (CRCs), to immunotherapies is attributed to the immunosuppressive tumor microenvironment that protects malignant cells from cytotoxic T lymphocytes (CTLs). We found that downregulation...
3.
Katlinskaya Y, Carbone C, Yu Q, Fuchs S
Cancer Biol Ther
. 2015 Jun;
16(8):1214-9.
PMID: 26046815
The major known function of cytokines that belong to type I interferons (IFN, including IFNα and IFNβ) is to mount the defense against viruses. This function also protects the genetic...
4.
Yu Q, Katlinskaya Y, Carbone C, Zhao B, Katlinski K, Zheng H, et al.
Cell Rep
. 2015 Apr;
11(5):785-797.
PMID: 25921537
Expression of type I interferons (IFNs) can be induced by DNA-damaging agents, but the mechanisms and significance of this regulation are not completely understood. We found that the transcription factor...
5.
Yu Q, Carbone C, Katlinskaya Y, Zheng H, Zheng K, Luo M, et al.
J Biol Chem
. 2015 Feb;
290(16):10191-9.
PMID: 25716322
Type I interferons (IFN) including IFNα and IFNβ are critical for the cellular defense against viruses. Here we report that increased levels of IFNβ were found in testes from mice...
6.
Bhattacharya S, Katlinski K, Reichert M, Takano S, Brice A, Zhao B, et al.
EMBO Mol Med
. 2014 Feb;
6(3):384-97.
PMID: 24480543
Type 1 interferons (IFN) protect the host against viruses by engaging a cognate receptor (consisting of IFNAR1/IFNAR2 chains) and inducing downstream signaling and gene expression. However, inflammatory stimuli can trigger...
7.
Zheng H, Gupta V, Patterson-Fortin J, Bhattacharya S, Katlinski K, Wu J, et al.
Cell Rep
. 2013 Oct;
5(1):180-93.
PMID: 24075985
Lysine63-linked ubiquitin (K63-Ub) chains represent a particular ubiquitin topology that mediates proteasome-independent signaling events. The deubiquitinating enzyme (DUB) BRCC36 segregates into distinct nuclear and cytoplasmic complexes that are specific for...
8.
Carbone C, Fuchs S
J Cell Biochem
. 2013 Aug;
115(1):8-16.
PMID: 23959845
Activation of cytokine receptor-associated Janus kinases (JAKs) mediates most, if not all, of the cellular responses to peptide hormones and cytokines. Consequently, JAKs play a paramount role in homeostasis and...
9.
Carbone C, Zheng H, Bhattacharya S, Lewis J, Reiter A, Henthorn P, et al.
Proc Natl Acad Sci U S A
. 2012 Nov;
109(47):19226-31.
PMID: 23129613
Type 1 interferons (IFN1) elicit antiviral defenses by activating the cognate receptor composed of IFN-α/β receptor chain 1 (IFNAR1) and IFNAR2. Down-regulation of this receptor occurs through IFN1-stimulated IFNAR1 ubiquitination,...
10.
Zheng H, Qian J, Carbone C, Leu N, Baker D, Fuchs S
Blood
. 2011 Aug;
118(14):4003-6.
PMID: 21832278
Angiogenesis is stimulated by vascular endothelial growth factor (VEGF) and antagonized by type 1 interferons, including IFN-α/β. On engaging their respective receptors (VEGFR2 and IFNAR), both stimuli activate protein kinase...