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Christopher Hug

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Articles 24
Citations 1698
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Recent Articles
1.
Lee M, North C, Choudhuri I, Biswas S, Fleisch A, Farooque A, et al.
medRxiv . 2024 Oct; PMID: 39399016
Arsenic is associated with lung disease and experimental models suggest that arsenic-induced degradation of the chloride channel CFTR (cystic fibrosis transmembrane conductance regulator) is a mechanism of arsenic toxicity. We...
2.
Mazumdar M, Wang X, Biswas S, Biswas P, Farooque A, Lee M, et al.
Environ Epidemiol . 2024 Aug; 8(5):e330. PMID: 39175802
Background: Arsenic has been associated with diabetes and impaired glucose tolerance in many studies, although some reports have shown null findings. Methods: We conducted a cross-sectional study among 300 adults...
3.
Diaz-Manera J, Kishnani P, Kushlaf H, Ladha S, Mozaffar T, Straub V, et al.
Lancet Neurol . 2021 Nov; 20(12):1012-1026. PMID: 34800399
Background: Pompe disease is a rare, progressive neuromuscular disorder caused by deficiency of acid α-glucosidase (GAA) and accumulation of lysosomal glycogen. We assessed the safety and efficacy of avalglucosidase alfa,...
4.
Amarsaikhan N, Tsoggerel A, Hug C, Templeton S
J Immunol . 2019 Jun; 203(4):956-963. PMID: 31253725
Systemic immunity and metabolism are coregulated by soluble factors, including the insulin-regulating adipose tissue cytokine adiponectin. How these factors impact detrimental inflammatory responses during fungal infection remains unknown. In this...
5.
Little H, Tan S, Cali F, Rodriguez S, Lei X, Wolfe A, et al.
Mol Cell Proteomics . 2018 May; 17(8):1546-1563. PMID: 29735541
Exercise is known to confer major health benefits, but the underlying mechanisms are not well understood. The systemic effects of exercise on multi-organ systems are thought to be partly because...
6.
Lai P, Allen J, Hutchinson D, Ajami N, Petrosino J, Winters T, et al.
PLoS One . 2017 Jul; 12(7):e0180969. PMID: 28704437
Objectives: To characterize the microbial environment of workers in academic mouse research facilities using endotoxin, 16S qPCR, and 16S amplicon sequencing. To determine whether the work microbiome contributes to the...
7.
Ratjen F, Hug C, Marigowda G, Tian S, Huang X, Stanojevic S, et al.
Lancet Respir Med . 2017 Jun; 5(7):557-567. PMID: 28606620
Background: Lumacaftor and ivacaftor combination treatment showed efficacy in patients aged 12 years or older with cystic fibrosis homozygous for F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in placebo-controlled studies and...
8.
Mazumdar M, Christiani D, Biswas S, Ibne-Hasan O, Kapur K, Hug C
N Engl J Med . 2015 Feb; 372(6):582-4. PMID: 25651269
No abstract available.
9.
Kasahara D, Kim H, Mathews J, Verbout N, Williams A, Wurmbrand A, et al.
Am J Physiol Lung Cell Mol Physiol . 2014 Jan; 306(6):L508-20. PMID: 24381131
Adiponectin is an adipose-derived hormone with anti-inflammatory activity. Following subacute ozone exposure (0.3 ppm for 24-72 h), neutrophilic inflammation and IL-6 are augmented in adiponectin-deficient (Adipo(-/-)) mice. The IL-17/granulocyte colony-stimulating...
10.
Verbout N, Benedito L, Williams A, Kasahara D, Wurmbrand A, Si H, et al.
J Allergy (Cairo) . 2013 Jul; 2013:349520. PMID: 23861690
Obesity is an important risk factor for asthma. Obese individuals have decreased circulating adiponectin, an adipose-derived hormone with anti-inflammatory properties. We hypothesized that transgenic overexpression of adiponectin would attenuate allergic...