Christopher E Pope
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Explore the profile of Christopher E Pope including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
884
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Recent Articles
1.
Hodor P, Pope C, Whitlock K, McDonald P, Hauptman J, Hoffman L, et al.
PLoS One
. 2024 Oct;
19(10):e0311605.
PMID: 39388396
Shunt infections are a common complication when treating hydrocephalus by cerebrospinal fluid (CSF) shunt placement. The source of infecting pathogens is not well understood. One hypothesis, which we explored here,...
2.
Duong J, Pope C, Hayden H, Miller C, Salipante S, Rowe S, et al.
J Cyst Fibros
. 2024 Mar;
23(3):490-498.
PMID: 38448281
Background: Cystic fibrosis associated liver disease (CFLD) carries a significant disease burden with no effective preventive therapies. According to the gut-liver axis hypothesis for CFLD pathogenesis, dysbiosis and increased intestinal...
3.
Pandey S, Whitlock K, Test M, Hodor P, Pope C, Limbrick Jr D, et al.
PLoS One
. 2023 Jun;
18(6):e0280682.
PMID: 37342995
Objective: To characterize the microbiota of the cerebrospinal fluid (CSF) from children with hydrocephalus at the time of initial surgical intervention. Study Design: CSF was obtained at initial surgical intervention....
4.
Pope C, Whitlock K, Hodor P, Limbrick Jr D, McDonald P, Hauptman J, et al.
Microbiol Spectr
. 2023 May;
11(3):e0036123.
PMID: 37140368
Advances in both laboratory and computational components of high-throughput 16S amplicon sequencing (16S HTS) have markedly increased its sensitivity and specificity. Additionally, these refinements have better delineated the limits of...
5.
Eng A, Hayden H, Pope C, Brittnacher M, Vo A, Weiss E, et al.
BMC Microbiol
. 2021 Sep;
21(1):247.
PMID: 34525965
Background: Infants with cystic fibrosis (CF) suffer from gastrointestinal (GI) complications, including pancreatic insufficiency and intestinal inflammation, which have been associated with impaired nutrition and growth. Recent evidence identified altered...
6.
Hodor P, Pope C, Whitlock K, Hoffman L, Limbrick D, McDonald P, et al.
Front Cell Infect Microbiol
. 2021 Sep;
11:699506.
PMID: 34490140
Understanding the etiology of cerebrospinal fluid (CSF) shunt infections and reinfections requires detailed characterization of associated microorganisms. Traditionally, identification of bacteria present in the CSF has relied on culture methods,...
7.
Whitlock K, Pope C, Hodor P, Hoffman L, Limbrick Jr D, McDonald P, et al.
PLoS One
. 2021 Jan;
16(1):e0244643.
PMID: 33406142
Background: Nearly 20% of patients with cerebrospinal fluid (CSF) shunt infection develop reinfection. It is unclear whether reinfections are caused by an organism previously present or are independent infection events....
8.
Meeker S, Mears K, Sangwan N, Brittnacher M, Weiss E, Treuting P, et al.
PLoS Pathog
. 2020 Jan;
16(1):e1008251.
PMID: 31961914
Patients with cystic fibrosis (CF) have altered fecal microbiomes compared to those of healthy controls. The magnitude of this dysbiosis correlates with measures of CF gastrointestinal (GI) disease, including GI...
9.
Hayden H, Eng A, Pope C, Brittnacher M, Vo A, Weiss E, et al.
Nat Med
. 2020 Jan;
26(2):215-221.
PMID: 31959989
Most infants with cystic fibrosis (CF) have pancreatic exocrine insufficiency that results in nutrient malabsorption and requires oral pancreatic enzyme replacement. Newborn screening for CF has enabled earlier diagnosis, nutritional...
10.
Ross B, Verster A, Radey M, Schmidtke D, Pope C, Hoffman L, et al.
Nature
. 2019 Nov;
575(7781):224-228.
PMID: 31666699
The human gastrointestinal tract consists of a dense and diverse microbial community, the composition of which is intimately linked to health. Extrinsic factors such as diet and host immunity are...